Imaging Insights on the Aorta in Aging.
Imaging Insights on the Aorta in Aging.
复制标题
DOI：
10.1161/circimaging.117.005617
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Lima JAC
中科院分区：
文献类型：
--
作者：
Ohyama Y;Redheuil A;Kachenoura N;Ambale Venkatesh B;Lima JAC
主动脉有两个主要功能：导管和缓冲垫，旨在将血液输送到外周并缓冲心室收缩产生的脉动应力。在主动脉结构和功能变化之间的相互作用中，衰老和疾病过程会影响主动脉材料特性和血流动力学。为了全面评估与衰老和疾病相关的主动脉结构和功能的变化，最近开发了无创心血管成像技术，特别是磁共振成像（MRI）。 MRI 可直接、准确地测量不同的主动脉特征，包括主动脉面积或体积、主动脉长度、曲率和主动脉壁厚度等结构测量，以及主动脉应变、扩张性和脉搏波速度 (PWV) 等功能测量。 MRI 方法出色的重现性使我们能够评估整个主动脉对药物和非药物治疗的反应。主动脉血流和功能评估可以作为一种综合成像方式添加到临床常规 CMR 中，主要用于左室功能、左室负荷和血管/心室耦合的无创评估。 4D 血流等新技术可以进一步阐明主动脉几何形状和功能改变与年龄相关的综合影响。以下综述将描述主动脉的病理生理学方面，以及心血管成像（尤其是 MRI）的能力、价值和前景，以研究主动脉结构和功能的年龄相关变化，并评估这些变化与心血管疾病 (CVD) 之间的关系。
The aorta has two main functions: conduit and cushion, and is designed to transmit blood to the periphery and buffer pulsatile stress from ventricular contraction. In the interaction between the structural and functional changes of the aorta, aging and disease processes impact on aortic material properties and hemodynamics. For a comprehensive assessment of changes in aortic structure and function associated with aging and disease, noninvasive cardiovascular imaging techniques, especially magnetic resonance imaging (MRI), have recently been developed. MRI allows for direct and accurate measurement of different aortic characteristics including structural measures such as aortic area or volume, aortic length, curvature, and aortic wall thickness, as well as functional measures such as aortic strain, distensibility, and pulse wave velocity (PWV). Excellent reproducibility of MRI methods allows us to assess the response of the whole aorta to both pharmacologic and non-pharmacologic therapy. Aortic flow and functional assessment could be added to clinical routine CMR as a comprehensive imaging modality primarily performed for the noninvasive evaluation of LV function, LV load, and vascular/ventricular coupling. New techniques such as 4D flow could provide further elucidate the combined age-related effects of altered aortic geometry and function. This following review will describe the pathophysiological aspects of the aorta, and the ability, value, and prospects of cardiovascular imaging, especially MRI, to study age-related changes in aortic structure and function and assess the relationship between these alterations and cardiovascular disease (CVD).