New perspectives in a gustatory physiology: transduction, development, and plasticity.
New perspectives in a gustatory physiology: transduction, development, and plasticity.
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DOI：
10.1152/ajpcell.1997.272.1.c1
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
R. E. Stewart;J. DeSimone;D. Hill
中科院分区：
文献类型：
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作者：
R. E. Stewart;J. DeSimone;D. Hill
在过去的十年里，对哺乳动物味觉转导机制的理解取得了重大进展。最近的研究表明，味觉刺激的接受涉及到显著不同的细胞机制。这些机制从G蛋白和第二信使连接的受体系统到刺激门控和刺激接纳离子通道。与广泛持有的观点相反，新的数据显示，一些味觉刺激与位于味觉细胞顶端和基侧膜上的感受部位相互作用。对几个物种味觉系统发育的研究表明，某些刺激的转导通路在出生后的早期受到显著的调节。此外，最近对成人外周味觉系统可塑性的研究强烈表明，Na+感觉系统的功能可以受到循环中的激素、生长因子或细胞因子的调节。
Major advances in the understanding of mammalian gustatory transduction mechanisms have occurred in the past decade. Recent research has revealed that a remarkable diversity of cellular mechanisms are involved in taste stimulus reception. These mechanisms range from G protein-and second messenger-linked receptor systems to stimulus-gated and stimulus-admitting ion channels. Contrary to widely held ideas, new data show that some taste stimuli interact with receptive sites that are localized on both the apical and basolateral membranes of taste cells. Studies of taste system development in several species indicate that the transduction pathways for some stimuli are modulated significantly during the early postnatal period. In addition, recent investigations of adult peripheral gustatory system plasticity strongly suggest that the function of the Na+ sensing system can be modulated by circulating hormones, growth factors, or cytokines.