NW-G12, a Novel Nonchlorinated Cyclohexapeptide from Streptomyces alboflavus 313
NW-G12, a Novel Nonchlorinated Cyclohexapeptide from Streptomyces alboflavus 313
复制标题
NW-G12，一种来自白黄链霉菌 313 的新型非氯化环六肽
DOI：
10.1007/s10600-013-0775-x
复制
发表时间：
2013-11-01
影响因子：
0.8
通讯作者：
Wu, Wenjun
中科院分区：
文献类型：
--
作者：
Fan, Lixia;Ji, Zhiqin;Wu, Wenjun
在对白黄链霉菌313代谢产物的研究中，我们在弱极性部分得到了一种新的NW-G 01的非氯代类似物NW-G12（1），并在强极性部分的发酵液中分离到一种已知的沙漠霉素A（2）。化合物1和2的结构通过1D和2D NMR数据的综合分析确定。此外，化合物1和2对蜡状芽孢杆菌、金黄色葡萄球菌和枯草芽孢杆菌显示出较强的抗菌活性，MIC小于10 μ g/mL，但对两种革兰氏阴性菌均不显示抗菌活性。
In our continuous investigation of metabolites of Streptomyces alboflavus 313, NW-G12 (1), a novel nonchlorinated analogue of NW-G01, was obtained as a trace constituent in the weak polarity part and a known desertomycin A (2) was also isolated from the fermentation broth in the strong polarity part. The structures of compounds 1 and 2 were established by comprehensive analysis of 1D and 2D NMR spectral data. Moreover, compounds 1 and 2 showed strong antibacterial activities against Bacillus cereus, Staphylococcus aureus, and Bacillus subtilis, with MICs of less than 10 mu g/mL, but both show no antibacterial activities against two gram-negative bacteria.