ANTIGENIC GROUPINGS OF 90 RHINOVIRUS SEROTYPES
ANTIGENIC GROUPINGS OF 90 RHINOVIRUS SEROTYPES
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DOI：
10.1128/iai.37.2.642-647.1982
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
KENNY, GE
中科院分区：
文献类型：
--
作者：
COONEY, MK;FOX, JP;KENNY, GE
使用先前描述的方法在兔子中生产了针对 90 种鼻病毒血清型的有效抗血清。通过中和试验进行的系统测试揭示了鼻病毒类型之间存在大量的交叉关系，其中一些已经被报道过。在此，将观察结果与美国国立卫生研究院参考豚鼠抗血清中报告的交叉反应进行比较。原始鼻病毒分离株代表已知与其他鼻病毒有抗原相关性的血清型，并针对相关血清型的兔抗血清进行了测试。这些测试显示，鼻病毒12:78或36:58（它们是相互相关的对）、41（与13相互相关）和67（与9和32均相关）等分离株之间存在广泛的抗原变异。如果根据抗原关系对鼻病毒血清型进行分组，则可以将50种类型分为16组。
Production in rabbits of potent antisera to the 90 classified rhinovirus serotypes was completed using previously described methods. Systematic testing by neutralization tests has revealed significant numbers of cross-relationships among rhinovirus types, some of which have already been reported. Herein, the observations are compared with cross-reactions reported in National Institutes of Health reference guinea pig antisera. Original rhinovirus isolates, representing serotypes known to be antigenically related to other rhinoviruses, were tested against rabbit antisera to the related serotypes. These tests revealed extensive antigenic variation among isolates identified as rhinovirus 12:78 or 36:58, which are reciprocally related pairs, 41, reciprocally related to 13, and 67, which is related to both 9 and 32. If the rhinovirus serotypes were grouped according to antigenic relationships, 50 types could be included in 16 groups.