OSTEOREGULATORY NATURE OF MECHANICAL STIMULI - FUNCTION AS A DETERMINANT FOR ADAPTIVE REMODELING IN BONE
OSTEOREGULATORY NATURE OF MECHANICAL STIMULI - FUNCTION AS A DETERMINANT FOR ADAPTIVE REMODELING IN BONE
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DOI：
10.1002/jor.1100050217
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发表时间：
1987-01-01
影响因子：
2.8
通讯作者：
LANYON, LE
中科院分区：
文献类型：
--
作者：
RUBIN, CT;LANYON, LE
使用功能分离的火鸡尺骨制剂研究了骨骼内的功能适应能力。这项研究的结果表明，适应性骨重塑对骨组织内产生的应变的大小和分布的变化极其敏感。目前看来，加载机制只有在本质上是动态的时才能影响骨重塑。只需极短时间接触该刺激，即可充分发挥其影响的成骨潜力。刺激的效力似乎与产生的应变的大小成正比。由于一个位置可接受的应变水平会引起其他位置的适应性重塑，因此每块骨头的每个区域似乎都经过“基因编程”，以接受特定数量和模式的间歇性应变为“正常”。偏离“最佳应变环境”将刺激骨骼重塑平衡的变化，导致其质量适应性增加或减少。
The capacity for functional adaptation within the skeleton was studied using the functionally isolated turkey ulna preparation. The results of this study would suggest that adaptive bone remodeling is extremely sensitive to alterations in both the magnitude and distribution of the strain generated within the bone tissue. At present, it appears that a loading regime can only influence bone remodeling when it is dynamic in nature. The full osteogenic potential of its influence is then achieved after only an extremely short exposure to this stimulus. The potency of the stimulus appears to be proportional to the magnitude of the strain engendered. As strain levels that are acceptable in one location induce adaptive remodeling in others, it would appear that each region of each bone is "genetically programed" to accept a particular amount and pattern of intermittent strain as "normal". Deviation from the "optimal strain environment" will stimulate changes in the bone''s remodeling balance, resulting in adaptive increases or decreases in its mass.