Modulation of life and death by the TNF receptor superfamily
Modulation of life and death by the TNF receptor superfamily
复制标题
DOI：
10.1038/sj.onc.1202568
复制
发表时间：
1998-12-24
期刊：
影响因子：
8
通讯作者：
Reddy, EP
中科院分区：
文献类型：
--
作者：
Baker, SJ;Reddy, EP
肿瘤坏死因子受体（TNFR）超家族是一个不断增长的家族，迄今已在哺乳动物细胞中发现了20多个成员。这些蛋白在其细胞外配体结合域和细胞内效应（死亡）域具有显著的同源性。这些受体似乎通过蛋白质-蛋白质相互作用传递信号，传递死亡或生存信号。含有死亡结构域的蛋白（TRADD, FADD/MORT-1， RIP），含有TRAF结构域的蛋白（TRAF1-6）以及新成员和接头蛋白（如DAXX）的分离和表征为我们理解与该受体家族相关的信号机制提供了新的见解。虽然死亡信号似乎与caspase和JUN激酶途径的激活有关，但生存信号是通过NF-kappa B途径的激活介导的。
The tumor necrosis factor receptor (TNFR) superfamily represents a growing family, with over 20 members having been identified thus far in mammalian cells. These proteins share significant homologies in their extracellular ligand binding domains and intracellular effector (death) domains. These receptors appear to transmit their signals via protein-protein interactions, which convey either a death or survival signal. Isolation and characterization of death domain containing proteins (TRADD, FADD/MORT-1, RIP), TRAF domain containing proteins (TRAF1-6) as well as new members and adaptor proteins such as DAXX have provided new insights to our understanding of signaling mechanisms associated with this family of receptors, While the death signals seem to be associated,vith the activation of both the caspase and JUN kinase pathways, the survival signals are mediated via the activation of the NF-kappa B pathway.