Cell commitment and differentiation
Cell commitment and differentiation
复制标题
细胞定型和分化
DOI：
10.1016/0014-5793(88)80682-3
复制
发表时间：
1988
期刊：
影响因子：
3.5
通讯作者：
C. C. Ford
中科院分区：
文献类型：
--
作者：
C. C. Ford
当我第一次拿起这本书时，我想知道作者所说的“承诺”是什么意思。这本书的一个有价值的特点是，所使用的中心术语是在第一章中定义的。因此，承诺被认为是“对特定的专业命运的相对稳定的奉献，无论是潜在的还是已实现的”。因此，这个术语包括决定（也被定义），并导致细胞获得不同的形态、功能和组成（分化状态）。这本书的目的是提供多种过程的合成，可以有助于从一个受精卵产生许多专门的细胞类型。这是一个很大的话题，可能会包括整个发育生物学。然而，它肯定不是“另一本发育生物学教科书”。背景胚胎学，除了在特殊情况下，没有给出，而在细胞生物学，细胞生物化学和遗传学的合理背景也假设。这本书是针对先进的本科生和其他有兴趣在这个多方面的主题的当前概述。在导论章之后，剩下的十章涵盖了基因组恒常性和核全能性、基因的作用和调控、细胞表面、细胞外环境、早期胚胎、胚胎到成体的决定和分化的稳定性、生长形式和一些模式系统。最后一章试图综合前几章中发展起来的各种线索。这本书的总体长度是这样的，可以从头读到尾，这是一个很好的特点，关系到发展概述。交叉引用也被大量使用，使得从不同角度考虑同一个问题的章节跳转到章节变得很容易。具体的例子与选定的参考文献（通常是评论），以便
When I first picked up this book I wondered what the authors meant by ‘commitment’. One of the valuable features of the book is that the central terms used are defined in the opening chapter. Thus commitment is taken as ‘the relatively stable dedication to a particular specialized fate, either potential or realized’. The term, therefore, includes determination (which is also defined) and leads the cell to the acquisition of a distinct morphology, function and composition (the differentiated state). The aim of the book is to provide a synthesis of the multiple processes that can contribute to the generation of many specialized cell types from a single fertilized egg. This is a large topic and might be expected to encompass the whole of developmental biology. However, it is certainly not ‘another developmental biology text’. Background embryology, other than in special instances, is not given, while a reasonable background in cell biology, cellular biochemistry and genetics is also assumed. The book is aimed at advanced undergraduates and others interested in a current overview of this multifaceted topic.After the introductory chapter, the remaining ten chapters cover genomic constancy and nuclear totipotency, gene action and regulation, the cell surface, the extracellular environment, the early embryo, the stability of determination and differentiation from embryo to adult, growth form and some model systems. The final chapter attempts a synthesis of the variety of threads developed in the previous chapters. The overall length is such that the book can be read from cover to cover, a good feature in relation to developing an overview. Cross references are also used liberally, making it easy to jump from chapter to chapter where the same problem is considered from different perspectives. Specific examples are given with selected references (often reviews) so that the