HEMOSTATIC ABNORMALITIES IN DOGS WITH HEMANGIOSARCOMA
HEMOSTATIC ABNORMALITIES IN DOGS WITH HEMANGIOSARCOMA
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DOI：
10.1111/j.1939-1676.1991.tb00923.x
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发表时间：
1991-01-01
影响因子：
2.6
通讯作者：
GETZY, D
中科院分区：
文献类型：
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作者：
HAMMER, AS;COUTO, CG;GETZY, D
对24只经组织学证实的犬血管肉瘤的止血情况进行了前瞻性评估。微血管病理性溶血的定义为血细胞的存在；弥散性血管内凝血的定义为1)血小板减少，2)纤维蛋白(原)降解产物>；10-mU·g/ml，3)一次或多次凝血时间(激活的部分凝血活酶时间或一期凝血酶原时间)延长超过对照组的25%，4)碎裂的红细胞(根据半定量分级标准大于或等于1+)，5)纤维蛋白原低于或等于80 mg/dL。要诊断弥散性血管内凝血，必须满足上述五项标准中的三项。50%的狗在发病时被认为患有弥散性血管内凝血。75%的狗出现了血小板减少，这是最常见的异常。平均血小板计数为137,800个/mU·L。25%的狗死于止血异常。只有12%的狗有微血管病理性溶血，没有其他弥漫性血管内凝血的证据。许多患血管肉瘤的狗在最初的临床表现中都存在止血异常，这是一个重要的临床发现。
The hemostasis profiles of 24 dogs with histologically confirmed hemangiosarcoma were prospectively evaluated. Microangiopathic hemolysis was defined as the presence of schistocytes; disseminated intravascular coagulation was defined as 1) thrombocytopenia, 2) fibrin(ogen) degradation products > 10-mu-g/mL, 3) prolongation of one or more coagulation times (activated partial thromboplastin time or one-stage prothrombin time) by greater than 25% of the control, 4) fragmented red blood cells (greater-than-or-equal-to 1 + based on a semiquantitative grading scale), and 5) fibrinogen less-than-or-equal-to 80 mg/dL. Three of the five criteria listed above had to be met for disseminated intravascular coagulation to be diagnosed. Fifty percent of the dogs were considered to have disseminated intravascular coagulation at presentation. Thrombocytopenia was present in 75% of the dogs and was the most common abnormality. The mean platelet count was 137,800/mu-L. Twenty-five percent of the dogs died as a result of the hemostatic abnormalities. Only 12% of the dogs had microangiopathic hemolysis without other evidence of disseminated intravascular coagulation. Hemostatic abnormalities are present in many dogs with hemangiosarcoma at the initial clinical presentation and represent an important clinical finding.