The relationship between reaction time and response variability and somatosensory No-go potentials
The relationship between reaction time and response variability and somatosensory No-go potentials
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DOI：
10.1007/s00421-011-1973-5
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Kakigi, Ryusuke
中科院分区：
文献类型：
--
作者：
Nakata, Hiroki;Sakamoto, Kiwako;Kakigi, Ryusuke
我们研究了反应时(RT)与反应变异性和体感GO/NO-GO电位之间的关系。记录了16名受试者左手第二指(Go刺激)或第五指(No-Go刺激)电刺激后的事件相关电位，Go刺激和No-Go刺激以均匀的概率出现。研究人员要求受试者用右手拇指按下按钮，对围棋刺激做出反应。分析RT与N140、P300成分的相关性，以及RT与N140、P300的标准差之间的相关性。No-Go-N140(由No-Go刺激诱发的N140)和Go-N140(由Go刺激诱发的N140)的波幅和潜伏期与RT和RT的SD均无明显关系。RT与Fz、C3的No-Go-P300(No-Go刺激诱发的P300)波幅呈显著负相关，提示RT较短的受试者有较大的No-Go-P300波幅。Pz和C3的Go-P300潜伏期与RT显著相关。RT的SD与C3的No-Go-P300和Pz、C4的Go-P300波幅、Cz的No-Go-P300和Fz、Cz、Pz、C3、C4的Go-P300潜伏期显著相关。我们的结果表明，在Go/No-Go范式中，对Go刺激的反应速度和变异性影响了对No-Go刺激的No-Go相关神经活动。
We investigated the relationship between reaction time (RT) and response variability and somatosensory Go/No-go potentials. Event-related potentials following electrical stimulation of the second (Go stimulus) or fifth (No-go stimulus) digit of the left hand were recorded from 16 subjects, and Go and No-go stimuli were presented at an even probability. The subjects were instructed to respond to the Go stimuli by pushing a button with their right thumb. We analyzed the correlation between RT and the N140 and P300 components, and between the standard deviation (SD) of RT and the N140 and P300. Neither the amplitude nor latency of the No-go-N140 (N140 evoked by No-go stimuli) or the Go-N140 (N140 evoked by Go stimuli) related significantly with RT and the SD of RT. There was a significant negative correlation between RT and the amplitude of the No-go-P300 (P300 evoked by No-go stimuli) at Fz and C3, indicating that subjects with a shorter RT had a No-go-P300 of larger amplitude. The latency of the Go-P300 (P300 evoked by Go stimuli) at Pz and C3 showed a significant correlation with RT. The SD of RT was significantly correlated with the amplitudes of the No-go-P300 at C3 and Go-P300 at Pz and C4, and the latency of the No-go-P300 at Cz and Go-P300 at Fz, Cz, Pz, C3, and C4. Our results suggest that response speed and variability for the Go stimulus in Go/No-go paradigms affect No-go-related neural activity for the No-go stimulus.