Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis
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DOI：
10.1016/j.brainresrev.2004.07.011
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发表时间：
2004-12-01
影响因子：
--
通讯作者：
Gysling, K
中科院分区：
文献类型：
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作者：
Forray, MI;Gysling, K
终纹床核（bed nucleus of the stria terminalis，BNST）在应激时对下丘脑-垂体-肾上腺（hypothalamic-pituitary-adrenal，HPA）轴的调节中起重要作用，是杏仁核和海马到下丘脑室旁核（paraventricnucleus of the hypothalamic，PVN）的重要下丘脑外中继。在这篇综述中，我们讨论了解剖，神经化学和行为学证据，证实了前BNST的去甲肾上腺素能终端在HPA轴的调节作用。我们提出的假设，BNST去甲肾上腺素（NA）参与调节海马抑制性影响HPA轴激活。NA对BNST前部的突触能传递产生紧张性抑制作用的观察结果支持了这一假设。我们还讨论了已知的机制参与BNST NA细胞外水平的调节和NA和促肾上腺皮质激素释放激素（CRH）之间的可能的相互作用，和CRH与谷氨酸（GLU）在HPA轴的活动的调节所施加的BNST。本综述中讨论的证据表明，BNST作为一个关键的下丘脑外中心，中继和整合边缘系统和自主神经系统的信息有关的压力反应，这表明在BNST的功能失调可能是压力相关的精神疾病的病理生理基础。(C)2004 Elsevier B.V保留所有权利。
The bed nucleus of the stria terminalis (BNST) plays an important role in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis during stress and it is a major extrahypothalamic relay to the paraventricular nucleus of the hypothalamus (PVN) from the amygdala and the hippocampus. In this review, we discuss the anatomical, neurochemical and behavioral evidence that substantiate a role for noradrenergic terminals of the anterior BNST in the regulation of the HPA axis. We propose the hypothesis that BNST noradrenaline (NA) participates in the regulation of the hippocampal inhibitory influence on the HPA axis activation. The observation that NA exerts a tonic inhibitory effect upon glutamatergic transmission in the anterior BNST supports this hypothesis. We also discuss the known mechanisms involved in the regulation of BNST NA extracellular levels and the possible interactions between NA and corticotropin-releasing hormone (CRH), and of CRH with glutamate (GLU) in the regulation of the HPA axis activity exerted by the BNST. The evidence discussed in the present review situates the BNST as a key extrahypothalamic center that relays and integrates limbic and autonomic information related to stress responses suggesting that dysregulation in the functioning of the BNST may underlie the pathophysiology of stress-related psychiatric disorders. (C) 2004 Elsevier B.V All rights reserved.