Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
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DOI：
10.1016/j.bbi.2013.02.003
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发表时间：
2013-08
影响因子：
15.1
通讯作者：
McCusker, Robert H.
中科院分区：
文献类型：
--
作者：
Kelley, Keith W.;O'Connor, Jason C.;Lawson, Marcus A.;Dantzer, Robert;Rodriguez-Zas, Sandra L.;McCusker, Robert H.
老年抑郁症是一个代价高昂的健康问题，但人们对其生理基础知之甚少。全身性炎症使老年动物和人类的先天免疫系统敏感，但尚不清楚慢性低度感染是否会影响抑郁样行为的持续时间。在这份报告中，我们感染成年（4-6个月）和老年（20-24个月）Balb/c小鼠与牛分枝杆菌的减毒株，卡介苗（BCG），以诱导慢性感染。然后，我们测量了抑郁样行为，这些行为对人类炎症相关的临床抑郁症具有结构、面孔和预测有效性。暴露于BCG引起急性疾病反应在成年和老年小鼠。然而，疾病的行为延长老年小鼠，评估的运动和饲养活动。两种抑郁样行为的测量，即涉及蔗糖偏好和尾部悬挂的测试，都表明成年小鼠在接触BCG后1天和7天表现出抑郁样行为。然而，老年小鼠在感染后三周继续表达这两种抑郁样行为。BCG感染引起色氨酸catenin增加，如血浆犬尿氨酸/色氨酸比率显著升高所证明，其在感染后7天达到峰值。在老年小鼠中，更大的色氨酸催化剂持续时间更长，并在感染后21天保持升高。这一发现与老年小鼠抑郁样行为持续时间延长一致。这些是使用慢性感染模型的第一个数据，以确定从炎症诱导的抑郁样行为和色氨酸卡替林的恢复在老年动物中延长。
Geriatric depression is a costly health issue, but little is known about its physiological underpinnings. Systemic inflammation sensitizes the innate immune system of aged animals and humans, but it is unknown if chronic, low-grade infections affect the duration of depressive-like behaviors. In this report, we infected adult (4–6 months) and aged (20–24 months) Balb/c mice with an attenuated strain of Mycobacterium bovis, Bacillus Calmette-Guérin (BCG), to induce a chronic infection. We then measured depression-like behaviors that have construct, face and predictive validity for human inflammation-associated clinical depression. Exposure to BCG caused acute sickness responses in both adult and aged mice. However, sickness behavior was prolonged in aged mice, as assessed by both locomotor and rearing activity. Two measures of depression-like behavior, which were tests involving sucrose preference and tail suspension, both showed that adult mice displayed depression-like behaviors at one day and seven days after exposure to BCG. However, aged mice continued to express both of these depression-like behaviors at three weeks following infection. Infection with BCG caused an increase in tryptophan catabolism, as evidenced by a significant rise in the plasma kynurenine/tryptophan ratio that peaked at 7 days post-infection. In aged mice, greater tryptophan catabolism persisted longer and remained elevated at 21 days post-infection. This finding is consistent with the prolonged duration of depression-like behaviors in aged mice. These are the first data using a chronic infection model to establish that recovery from inflammation-induced depression-like behavior and tryptophan catabolism are prolonged in aged animals.
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影响因子：
3.7
作者：
Frenois, Francois;Moreau, Maite;Castanon, Nathalie
通讯作者：
Castanon, Nathalie
影响因子：
--
作者：
Beekman, ATF;Geerlings, SW;van Tilburg, W
通讯作者：
van Tilburg, W
影响因子：
11
作者：
O'Connor, J. C.;Lawson, M. A.;Dantzer, R.
通讯作者：
Dantzer, R.
影响因子：
15.1
作者：
Abraham, Jayne;Johnson, Rodney W.
通讯作者：
Johnson, Rodney W.
影响因子：
3.7
作者：
Dantzer, Robert;O'Connor, Jason C.;Lawson, Marcus A.;Kelley, Keith W.
通讯作者：
Kelley, Keith W.