The medullary projections of afferent bronchopulmonary C fibres in the cat as shown by antidromic mapping.
The medullary projections of afferent bronchopulmonary C fibres in the cat as shown by antidromic mapping.
复制标题
猫传入支气管肺 C 纤维的髓质投影，如逆向映射所示。
DOI：
10.1113/jphysiol.1991.sp018506
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Davies,RO
中科院分区：
文献类型：
--
作者：
Kubin,L;Kimura,H;Davies,RO
1.在去大脑、瘫痪和人工呼吸猫的结状神经节细胞外记录了87个带无髓轴突的支气管肺迷走传入神经元(C纤维)的活动。根据右心房注射辣椒素或苯二胍后的反应潜伏期，可将这些细胞的感受器终末分为肺循环(潜伏期<3.5 S)或支气管(潜伏期>3.5 S)。2.肺和支气管受体细胞的反应特征(放电频率、爆发时程)和周围轴突的传导速度仅略有不同。支气管C纤维约占研究人群的70%。3.用逆行标测技术测定了6条肺和6条支气管C纤维的中枢支的髓内分布。这两种受体亚型在中枢投射模式上没有区别。4.在OBEX吻侧，支气管肺C纤维的中枢分支位于孤束核(NTS)内侧部和最后区，沿NTS的小细胞亚核边缘分布最为密集。在OBEX的尾侧，连合亚核的背侧部分分支最为密集。对侧NTS的投射被发现，但密度要低得多。5.支气管肺C纤维的中枢分布与参与呼吸和心血管控制的其他形式的迷走神经和舌咽传入的投射模式进行了比较。这一点是结合NTS特定模式组织的概念进行讨论的。
1. The activity of eighty‐seven bronchopulmonary vagal afferent neurones with unmyelinated axons (C fibres) was recorded extracellularly in the nodose ganglia of decerebrate, paralysed and artificially ventilated cats. On the basis of their response latencies following the right atrial injection of capsaicin or phenyldiguanide, the cells were classified as having their receptor endings within the reach of pulmonary (latency less than 3.5 s) or bronchial (latency above 3.5 s) circulation. 2. Pulmonary and bronchial receptor cells differed only slightly in their response characteristics (firing rate, burst duration) and the conduction velocity of their peripheral axons. Bronchial C fibres represented about 70% of the population studied. 3. The medullary distributions of the central branches of six pulmonary and six bronchial C fibres were determined by means of the antidromic mapping technique. The two receptor subtypes did not differ in their central projection patterns. 4. Rostral to the obex, the central branches of the bronchopulmonary C fibres were localized within the medial portions of the nucleus tractus solitarii (NTS) and area postrema, and were most densely distributed along the borders of the parvicellular subnucleus of the NTS. Caudal to the obex, the most dense branching was found in the dorsal portion of the commissural subnucleus. Projections to the contralateral NTS were found, but these were of a much lower density. 5. The central distribution of bronchopulmonary C fibres is compared to the projection patterns of vagal and glossopharyngeal afferents of other modalities that are involved in respiratory and cardiovascular control. This is discussed in relation to the concept of a modality‐specific organization of the NTS.