Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway
Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway
复制标题
双酚A和多氯联苯通过激活WNT信号通路增强人卵巢癌细胞的癌症干细胞特性
DOI：
10.1016/j.chemosphere.2019.125775
复制
发表时间：
2020-05-01
期刊：
影响因子：
8.8
通讯作者：
Zhang, Daoqiang
中科院分区：
文献类型：
--
作者：
Guo, Yifan;Li, Bin;Zhang, Daoqiang
癌症干细胞（CSC）是一个非常小的亚群，具有干细胞特性，如表现出自我更新，永生和多能性，以及分化成不同肿瘤细胞亚型的能力。CSC有助于肿瘤的发生、扩展、转移、抗性和复发。同时，有机污染物，包括非持久性污染物，如双酚A（BPA）和持久性污染物，如多氯联苯（PCB），是有毒化学品，可以通过饮食接触和其他接触途径容易摄入，并可以通过食物链积累。许多有机污染物会增加卵巢癌的风险，这取决于它们的雌激素效应。尽管如此，大多数以前的研究都集中在这些污染物对卵巢癌细胞增殖，转移和发展的毒性作用。然而，很少有研究调查这些污染物对卵巢癌干细胞的不利影响。目前的研究发现，BPA、PCB 126和PCB 153在低剂量暴露下极大地增强了OVCAR-3细胞（人卵巢癌细胞）的癌症干细胞样细胞球的形成。同时，相对于未处理的细胞，处理的细胞中的CD 44（高）CD 24（低）（）细胞亚群增加。与未处理的细胞相比，在处理的细胞中证实了癌症干细胞标志物（包括ALDH 1A 11、CD 133、SOX 2、NANOG和OCT 4）的表达升高。总之，这些数据表明，污染物的致癌效应可以根据癌症干细胞特性的变化进行评估。(C)2020爱思唯尔有限公司保留所有权利。
Cancer stem cells (CSCs) are a very small subpopulation that have stem-cell qualities, such as exhibiting self-renewal, immortality, and pluripotency, and the capability to differentiate into different tumor cell subtypes. CSCs contribute to tumor onset, expansion, metastasis, resistance and recurrence. Meanwhile, organic pollutants, including nonpersistent pollutants, such as bisphenol A (BPA), and persistent pollutants, such as polychlorinated biphenyls (PCBs), are toxic chemicals that can be readily ingested via dietary exposure and other exposure routes and can accumulate through the food chain. Many organic pollutants increase the risk of ovarian cancer depending on their estrogenic effects. Nonetheless, most previous studies have focused on the toxic effects of these pollutants on the proliferation, metastasis and development of ovarian cancer cells. However, little research has investigated the adverse effect of these pollutants on ovarian cancer stem cells. The current study found that BPA, PCB126 and PCB153 greatly enhanced the formation of cancer stem-like cell spheres of OVCAR-3 cells (human ovarian cancer cells) under low-dose exposure. In parallel, the CD44(high)CD24(low)( )cell subpopulation was increased in treated cells relative to untreated cells. Elevated expression of cancer stem cell markers, including ALDH1AI1, CD133, SOX2, NANOG and OCT4, was demonstrated in treated cells compared to untreated cells. In summary, these data demonstrate that the oncogenic effects of pollutants can be evaluated according to changes in caner stem cell properties. (C) 2020 Elsevier Ltd. All rights reserved.