Challenging sleep in aging:: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers
Challenging sleep in aging:: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers
复制标题
DOI：
10.1111/j.1365-2869.2006.00518.x
复制
发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Carrier, Julie
中科院分区：
文献类型：
--
作者：
Drapeau, Caroline;Hamel-Hebert, Isabelle;Carrier, Julie
本研究的目的是评估200毫克咖啡因对12名年轻（20-30岁）和12名中年（40-60岁）适度咖啡因消费者（每天1 - 3杯咖啡）的多导睡眠图睡眠变量和定量睡眠脑电图（EEG）的影响。所有受试者均采用双盲交叉设计，接受咖啡因（200 mg）和安慰剂（乳糖）。这些条件间隔1周。与安慰剂条件相比，晚上摄入咖啡因延长了睡眠潜伏期，降低了睡眠效率，并减少了两个年龄组的睡眠时间和第二阶段睡眠量。咖啡因还降低了额叶、中央和顶叶脑区δ频率的谱功率，但在前额（PF）和枕叶区没有。此外，咖啡因增加了两个年龄组额叶和中央脑区β频率的光谱功率。在低δ频率（0.5-1.00 Hz）下PF区频谱功率的抑制以及在高α（10.00-12.00 Hz）和β频率（17.00-21.00，23.00-25.00，27.00-29.00 Hz）下顶叶区频谱功率的升高仅发生在中年受试者中。在年轻的受试者中没有明显的变化。一般来说，咖啡因对年轻人和中年人产生了类似的影响。只有少数频率箱显示咖啡因对中年受试者的影响大于年轻受试者。此外，睡眠脑电图结果并不完全支持咖啡因完全模拟正常睡眠-觉醒周期后稳态睡眠倾向降低的影响的假设。
The aim of this study was to evaluate the effects of a 200-mg administration of caffeine on polysomnographic sleep variables and quantitative sleep electroencephalography (EEG) in 12 young (20-30 years) and 12 middle-aged (40-60 years) moderate caffeine consumers (one to three cups of coffee per day). All subjects were submitted to both a caffeine (200 mg) and placebo (lactose) condition in a double-blind cross-over design. The conditions were separated by 1 week. Compared with the placebo condition, the evening ingestion of caffeine lengthened sleep latency, reduced sleep efficiency, and decreased sleep duration and amount of stage 2 sleep in both age groups. Caffeine also reduced spectral power in delta frequencies in frontal, central and parietal brain areas, but not in prefrontal (PF) and occipital regions. Moreover, caffeine increased spectral power in beta frequencies in frontal and central brain areas in both age groups. A suppression of spectral power in the PF area in low delta frequencies (0.5-1.00 Hz) and a rise in spectral power in the parietal region in high alpha (10.00-12.00 Hz) and beta frequencies (17.00-21.00, 23.00-25.00, 27.00-29.00 Hz) occurred solely in middle-aged subjects. No such changes were noticeable in young subjects. Generally, caffeine produced similar effects in young and middle-aged subjects. Only a few frequency bins showed more effects of caffeine in middle-aged subjects compared with young subjects. Furthermore, sleep EEG results do not entirely support the hypothesis that caffeine fully mimics the effects of a reduction of homeostatic sleep propensity when following a normal sleep-wake cycle.