Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
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DOI：
10.1093/emboj/19.24.6664
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发表时间：
2000-12-15
期刊：
影响因子：
11.4
通讯作者：
Hogan, BLM
中科院分区：
文献类型：
--
作者：
Kulessa, H;Turk, G;Hogan, BLM
出生后毛囊的生长和分化是由毛乳头和周围的表皮毛发前体之间的相互作用控制的。这些相互作用的分子性质在很大程度上尚不清楚，但它们可能涉及几个信号分子家族，包括FGFs、WNTS和BMPs。为了分析BMP信号在出生后毛发发育中的功能，我们产生了在近端MSX2启动子的控制下表达BMP抑制物Noggin的转基因小鼠，MSX2启动子驱动增殖的毛发基质细胞和分化的毛发前体细胞表达。在MSX2-Noggin转基因小鼠中，毛干的分化而不是内根鞘的分化受到严重损害。除了毛发角蛋白，在转基因毛囊中，包括Foxn1和Hoxc13在内的几种与毛发发育有关的转录因子的表达严重减少，在前皮质和毛干区域发现了增殖细胞，这些细胞通常局限于毛乳头周围的毛发基质。这些结果表明，BMPS是控制出生后毛囊毛干分化的遗传程序的关键调节因子。
Growth and differentiation of postnatal hair follicles are controlled by reciprocal interactions between the dermal papilla and the surrounding epidermal hair precursors. The molecular nature of these interactions is largely unknown, but they are likely to involve several families of signaling molecules, including Fgfs, Wnts and Bmps, To analyze the function of Bmp signaling in postnatal hair development, we have generated transgenic mice expressing the Bmp inhibitor, Noggin, under the control of the proximal Msx2 promoter, which drives expression in proliferating hair matrix cells and differentiating hair precursor cells. Differentiation of the hair shaft but not the inner root sheath is severely impaired in Msx2-Noggin transgenic mice. In addition to hair keratins, the expression of several transcription factors implicated in hair development, including Foxn1 and Hoxc13, is severely reduced in the transgenic hair follicles, Proliferating cells, which are normally restricted to the hair matrix surrounding the dermal papilla, are found in the precortex and hair shaft region. These results identify Bmps as key regulators of the genetic program controlling hair shaft differentiation in postnatal hair follicles.