In vitro and in vivo effects of oxidative damage to deoxyguanosine
In vitro and in vivo effects of oxidative damage to deoxyguanosine
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DOI：
10.1042/bst0320046
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发表时间：
2004-02-01
影响因子：
3.9
通讯作者：
Greenberg, MM
中科院分区：
文献类型：
--
作者：
Greenberg, MM
在特定位点含有寡核苷酸损伤的生物化学、生物物理学和生物学研究为DNA损伤的影响提供了分子基础。脱氧鸟苷（dG）是四种天然核磷脂中最容易氧化的。dG的化学反应性与突变的编译相关，这表明转换或颠换的显著部分涉及dG。OxodG（7，8-dihydro-8-hydroxy 2 '-deoxyguanosine）是一种重要的脱氧鸟苷（dG）氧化损伤，对DNA结构和功能的影响已被广泛研究。最近，已经发现了衍生自dG和/或OxodG氧化的其他病变的性质。对这些病变的研究表明，它们也具有生物学意义。
Biochemical, biophysical and biological studies of oligonuclecitides containing lesions at defined sites provide a molecular basis for the effects of DNA lesions. dG (deoxyguanosine) is the most easily oxidized of the four native nuclecitides. The chemical reactivity of dG correlates with compilations of mutations, which reveal that a significant fraction of transitions or transversions involve dG. OxodG (7,8-dihydro-8-hydroxy2'-deoxyguanosine) is widely recognized as an important lesion derived from the oxidation of dG, and significant effort has been expended in studies of its effects on DNA structure and function. Recently, the properties of other lesions derived from dG and/or the oxidation of OxodG have been uncovered. Studies on these lesions reveal that they too are biologically significant.