Stimulated Raman Scattering Interferometer for Molecular-Selective Tomographic Imaging
Stimulated Raman Scattering Interferometer for Molecular-Selective Tomographic Imaging
复制标题
DOI：
10.1177/0003702817693232
复制
发表时间：
2017-03
影响因子：
3.5
通讯作者：
Motohiro Banno;Hiroharu Yui
中科院分区：
文献类型：
--
作者：
Motohiro Banno;Hiroharu Yui
介绍了一种受激拉曼散射（SRS）干涉仪的研制。在该装置中，在样品中产生的SRS信号与参考光束共线重叠，并且获得信号光束和参考光束之间的干涉图案。根据干涉图案，可以测量SRS信号的相位。根据信号的相位，可以以高定位精度获得目标分子的空间分布。本文研制了一台SRS干涉仪，首次从聚乙烯薄膜中获得了SRS干涉信号。测量了沿入射光传播方向沿着扫描样品位置所引起的SRS干涉图样的相位变化。从结果来看，检测到亚微米的样品位置差异，不确定度为15%。成功地获得了三层聚合物膜的断层图像。SRS干涉仪将成为新型分子选择性断层成像方法的核心光学技术。
Development of a stimulated Raman scattering (SRS) interferometer is presented. In the apparatus, a SRS signal generated in a sample is collinearly overlapped with a reference beam, and the interference pattern between the signal and reference beams is obtained. From the interference pattern, the phase of the SRS signal can be measured. From the phase of the signal, the spatial distribution of the target molecule can be obtained with high positioning precision. In the present article, the SRS interferometer was developed and the first SRS interference signal was obtained from a polyethylene film. The phase change of the SRS interference pattern caused by scanning the sample position along the direction of the incident light propagation was measured. From the result, the sample position difference for a sub-micron was detected with uncertainties of 15%. The tomographic images of a triple-layered polymer film were successfully obtained. The SRS interferometer would become a core optical technique of a novel molecular-selective tomographic imaging method.