Polyamines found in gingival fluid enhance the secretory and oxidative function of human polymorphonuclear leukocytes in vitro.
Polyamines found in gingival fluid enhance the secretory and oxidative function of human polymorphonuclear leukocytes in vitro.
复制标题
牙龈液中发现的多胺在体外增强人多形核白细胞的分泌和氧化功能。
DOI：
10.1111/j.1600-0765.1995.tb01269.x
复制
发表时间：
1995
影响因子：
3.5
通讯作者：
Chapman,KJ
中科院分区：
文献类型：
--
作者：
Walters,JD;Chapman,KJ
Many bacterial and host cells contain large amounts of polyamines that can be released at infection sites as a result of cell lysis. Consequently, the putrescine and spermidine content of gingival fluid from inflamed periodontal pockets (0.1 to 1 mM) is sharply elevated in comparison to peripheral blood. At these levels, polyamines potentiated fMet‐Leu‐Phe‐induced Ca2+signaling in polymorphonuclear leukocytes (PMNs)in vitro. Consistent with the essential role of Ca2+signaling in PMN activation, secondary granule release and superoxide anion production by fMet‐Leu‐Phe‐stimulated PMNs was enhanced in the presence of polyamines. Thus, polyamines may play a local role in modulating the antimicrobial activity of PMNs in periodontal disease.
