Dietary patterns and the risk of postmenopausal breast cancer in a German case-control study
Dietary patterns and the risk of postmenopausal breast cancer in a German case-control study
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DOI：
10.1007/s10552-010-9695-2
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发表时间：
2011-02-01
影响因子：
2.3
通讯作者：
Chang-Claude, Jenny
中科院分区：
文献类型：
--
作者：
Buck, Katharina;Vrieling, Alina;Chang-Claude, Jenny
饮食模式与乳腺癌风险的相关性并不一致。我们采用探索性方法评估了饮食模式与绝经后乳腺癌风险的关系。在一项绝经后乳腺癌风险的病例对照研究中，（年龄50-74岁）诊断之间，2002年和2005年在德国，信息来自食物频率问卷调查，其中2,884例和5，采用主成分因子分析法对509名对照进行膳食模式的识别。进行非条件logistic回归以计算针对饮食模式得分的最高与最低五分位数的潜在混杂因素调整的比值比（OR）。“健康”（包括高蔬菜和植物油摄入）和“不健康”（包括高肉类和油炸脂肪摄入）饮食模式。总体而言，未观察到饮食模式与乳腺癌风险之间的关联（OR = 1.04，95%置信区间（CI）=（0.88，1.23）和OR = 0.96，95% CI =（0.81，1.13））。ER/PR状态、体重指数、激素替代疗法的使用、教育、能量摄入和吸烟状况与绝经后乳腺癌的关系没有差异。总之，我们没有发现“健康”或“不健康”的饮食模式与绝经后乳腺癌风险之间的关系。
Dietary patterns have been inconsistently associated with breast cancer risk. We assessed dietary patterns in association with postmenopausal breast cancer risk using an exploratory approach.In a case-control study on postmenopausal breast cancer risk, including incident breast cancer cases (aged 50-74 years) diagnosed between 2002 and 2005 in Germany, information from a food frequency questionnaire among 2,884 cases and 5,509 controls was used for the identification of dietary patterns using principal component factor analysis. Unconditional logistic regression was performed to calculate odds ratios (ORs) adjusted for potential confounders for the highest versus the lowest quintile of dietary pattern score.Two major dietary patterns were identified, i.e., a "healthy" (including high vegetable and vegetable oil intake) and an "unhealthy" (including high meat and deep-frying fat intake) dietary pattern. Overall, no associations between the dietary patterns and breast cancer risk were observed (OR = 1.04, 95% confidence interval (CI) = (0.88, 1.23) and OR = 0.96, 95% CI = (0.81, 1.13), respectively). Associations did not differ by ER/PR status, body mass index, hormone replacement therapy use, education, energy intake, and smoking status.In conclusion, we did not find an association of a "healthy" or "unhealthy" dietary pattern with postmenopausal breast cancer risk.