BIOCHEMISTRY OF NITRIC-OXIDE AND ITS REDOX-ACTIVATED FORMS
BIOCHEMISTRY OF NITRIC-OXIDE AND ITS REDOX-ACTIVATED FORMS
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DOI：
10.1126/science.1281928
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发表时间：
1992-12-18
期刊：
影响因子：
56.9
通讯作者：
LOSCALZO, J
中科院分区：
文献类型：
--
作者：
STAMLER, JS;SINGEL, DJ;LOSCALZO, J
一氧化氮（NO.），一种潜在的有毒分子，涉及广泛的生物学功能。然而，其生物化学的细节仍然知之甚少。一氧化氮（NO）的更广泛的化学性质涉及具有独特性质和反应性的物质的氧化还原阵列：NO+（亚硝鎓），NO.，和NO-（硝酰基阴离子）。这种化学与NO生物学的当前观点的整合阐明了NO生物化学的许多方面，包括合成的酶机制，生物系统中的运输和靶向模式，减轻其毒性的方法，以及与靶蛋白的功能调节相互作用。
Nitric oxide (NO.), a potentially toxic molecule, has been implicated in a wide range of biological functions. Details of its biochemistry, however, remain poorly understood. The broader chemistry of nitrogen monoxide (NO) involves a redox array of species with distinctive properties and reactivities: NO+ (nitrosonium), NO., and NO- (nitroxyl anion). The integration of this chemistry with current perspectives of NO biology illuminates many aspects of NO biochemistry, including the enzymatic mechanism of synthesis, the mode of transport and targeting in biological systems, the means by which its toxicity is mitigated, and the function-regulating interaction with target proteins.