Reproductive aging: biological pathways and potential interventive strategies
Reproductive aging: biological pathways and potential interventive strategies
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DOI：
10.1016/j.jgg.2022.07.002
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发表时间：
2022
影响因子：
5.9
通讯作者：
Jinmin Gao
中科院分区：
文献类型：
--
作者：
Yuanyuan Liu;Jinmin Gao
Reproductive aging is a natural process conserved across species and is well-known in females. It shows age-related follicle depletion and reduction of oocyte quality, eventually causing reproductive senescence and menopause. Although reproductive aging in males is not well noticed as in females, it also causes infertility and has deleterious consequences on the offspring. Many factors have been suggested to contribute to reproductive aging, including oxidative stress, mitochondrial defects, telomere shortening, meiotic chromosome segregation errors, genetic alterations, etc. With the increasing trend of pregnancy age, it is particularly crucial to find interventions to preserve or extend human fertility. Studies in humans and model organisms have provided insights into the biological pathways associated with reproductive aging, and a series of potential interventive strategies have been tested. Here, we review factors affecting reproductive aging in females and males and summarize interventive strategies that may help delay or rescue the aging phenotypes of reproduction.
