Controlled drug release characteristics and enhanced antibacterial effect of graphene oxide-drug intercalated layered double hydroxide hybrid films
Controlled drug release characteristics and enhanced antibacterial effect of graphene oxide-drug intercalated layered double hydroxide hybrid films
复制标题
氧化石墨烯-药物插层层状双氢氧化物杂化薄膜的控释特性及增强抗菌作用
DOI：
10.1039/c2jm35144g
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发表时间：
2012-11-21
影响因子：
--
通讯作者：
Wan, Yi
中科院分区：
文献类型：
--
作者：
Wang, Yi;Zhang, Dun;Wan, Yi
采用简单的溶剂挥发法制备了氧化石墨烯-青霉素（BP）阴离子插层Mg-Al层状双氢氧化物（GO-BP-LDH）杂化膜。研究了BP阴离子的释放行为和抗菌活性。释放时间可以通过调节膜组成来定制，并且通过降低GO/BP-LDH质量比来增加。将释放动力学模型应用于药物释放过程，发现GO-BP-LDH杂化膜中BP阴离子的释放符合一级动力学模型。此外，与单一GO膜相比，杂化膜表现出更强的协同抗菌作用，这是由于杂化膜体系中GO和BP阴离子的协同抗菌作用。
Novel graphene oxide-benzylpenicillin (BP) anion intercalated Mg-Al layered double hydroxide (GO-BP-LDH) hybrid films were prepared via a simple solvent evaporation process. The release behaviour of BP anions and the antibacterial activity have also been investigated. The release time can be tailored by adjusting the film composition and increased by decreasing the GO/BP-LDH mass ratio. By applying release kinetic models to the drug release processes, the mechanism of release of BP anions from the GO-BP-LDH hybrid film was found to follow the first-order model. In addition, the hybrid film exhibited an enhanced synergistic antibacterial effect compared with the single GO film, which can be attributed to the combination of the antibacterial activity of GO and BP anions released from the hybrid film system.