Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men
Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men
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DOI：
10.1161/01.cir.100.7.723
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发表时间：
1999-08-17
期刊：
影响因子：
37.8
通讯作者：
Hamsten, A
中科院分区：
文献类型：
--
作者：
Boquist, S;Ruotolo, G;Hamsten, A
背景-营养性脂血症与冠心病和颈总动脉内膜中层厚度（IMT）有关。本研究旨在探讨餐后富含甘油三酯的脂蛋白（TRL）亚类与IMT的关系。方法和结果96例50岁健康男性，载脂蛋白（apo）E3/E3基因型，接受口服脂肪耐量试验和B型颈动脉超声检查。测定TRL各组分的apo B-48和apo B-100含量，作为乳糜微粒残留和VLDL颗粒浓度的量度。在空腹状态下，LDL胆固醇（P
Background-Alimentary lipemia has been associated with coronary heart disease and common carotid artery intima-media thickness (IMT). This study was designed to investigate the relations of subclasses of postprandial triglyceride-rich lipoproteins (TRLs) with IMT,Methods and Results-Ninety-six healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance test and B-mode carotid ultrasound examination. The apo B-48 and apo B-100 contents of each fraction of TRLs were determined as a measure of chylomicron remnant and VLDL particle concentrations. In the fasting state, LDL cholesterol (P