Molecular evolution of the NF-κB signaling system
Molecular evolution of the NF-κB signaling system
复制标题
DOI：
10.1007/s00251-001-0399-3
复制
发表时间：
2002-02-01
期刊：
影响因子：
3.2
通讯作者：
Hughes, AL
中科院分区：
文献类型：
--
作者：
Friedman, R;Hughes, AL
脊椎动物的天然免疫机制与昆虫的免疫机制有一定的相似性。有两种假说被提出来解释这些不一致性。(1)根据进化连续性假说，先天免疫机制在脊椎动物和昆虫的共同祖先中进化，并且自那时以来一直被保存下来。(2)在独立进化假说中，脊椎动物的先天免疫机制独立于无脊椎动物的免疫机制进化而来。使用五个基因家族（Pelle、Rel、IKB、Toll和TRAF）的系统发育分析来决定这些假设，所述五个基因家族的成员参与脊椎动物和昆虫中的NF-κ B信号传导。Rel和TRAF家族的同源性强有力地支持了脊椎动物和无脊椎动物中免疫功能的独立进化，并且除了Pelle家族中的可能情况之外，没有发现在脊椎动物和无脊椎动物中具有免疫功能的同源性分子。在脊椎动物和昆虫谱系中独立地被增选用于免疫系统作用的广义信号系统。
The mechanisms of innate immunity in vertebrates show certain overall resemblances to immune mechanisms of insects. Two hypotheses have been proposed to explain these resemblances. (1) According to the evolutionary continuity hypothesis, innate immune mechanisms evolved in the common ancestor of vertebrates and insects and have been conserved since that time. (2) In the independent-evolution hypothesis, the mechanisms of innate immunity in vertebrates evolved independently from invertebrate immune mechanisms. Phylogenetic analysis of five gene families (Pelle, Rel, IKB, Toll, and TRAF) whose members are involved in NF-KB signaling in vertebrates and insects were used to decide between these hypotheses. The phylogenies of the Rel and TRAF families strongly supported independent evolution of immune functions in vertebrates and invertebrates, and, except for a possible case in the Pelle family, orthologous molecules having immune functions in both vertebrates and invertebrates were not found. The results suggest that NF-KB represents an ancient, generalized signaling system that has been co-opted for immune system roles independently in vertebrate and insect lineages.