Potential protective mechanisms of green tea polyphenol EGCG against COVID-19.
Potential protective mechanisms of green tea polyphenol EGCG against COVID-19.
复制标题
绿茶多酚 EGCG 对 COVID-19 的潜在保护机制。
DOI：
10.1016/j.tifs.2021.05.023
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发表时间：
2021-08
影响因子：
15.3
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Zhang Z;Zhang X;Bi K;He Y;Yan W;Yang CS;Zhang J
世界正处于新冠肺炎大流行之中。在这篇综合综述中，我们讨论了绿茶的主要成分表没食子儿茶素没食子酸酯(−)对新冠肺炎的潜在保护作用。从新冠肺炎的临床症状和分子病理学的文献以及相关出版物中的信息进行综合和评估，其中EGCG显示了对新冠肺炎的潜在保护作用。EGCG通过激活Nrf2，抑制介导病毒进入细胞的ACE2(SARS-CoV-2细胞受体)和TMPRSS2。EGCG可能通过抑制SARS-CoV-2主要蛋白水解酶来抑制病毒复制。EGCG通过其广泛的抗氧化活性，可能对SARS-CoV-2引起的线粒体ROS(促进SARS-CoV-2复制)和中性粒细胞胞外陷阱引起的ROS爆发具有保护作用。通过抑制内质网驻留的GRP78活性和表达，EGCG可能抑制SARS-CoV-2的生命周期。EGCG还显示出对1)细胞因子风暴相关的急性肺损伤/急性呼吸窘迫综合征的保护作用，2)通过抑制组织因子和激活血小板而形成的血栓，3)通过灭活氧化还原敏感型HMGB1的败血症，以及4)通过增加Nrf2和抑制NF-κB的肺纤维化。这些活性仍有待在动物和人类中进一步证实。EGCG可能的协同作用表明了进一步研究新冠肺炎在人类中预防和治疗的重要性。这些结果还需要对饮用绿茶对新冠肺炎的潜在预防作用进行流行病学研究。
The world is in the midst of the COVID-19 pandemic. In this comprehensive review, we discuss the potential protective effects of (−)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, against COVID-19. Information from literature of clinical symptoms and molecular pathology of COVID-19 as well as relevant publications in which EGCG shows potential protective activities against COVID-19 is integrated and evaluated. EGCG, via activating Nrf2, can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2, which mediate cell entry of the virus. Through inhibition of SARS-CoV-2 main protease, EGCG may inhibit viral reproduction. EGCG via its broad antioxidant activity may protect against SARS-CoV-2 evoked mitochondrial ROS (which promote SARS-CoV-2 replication) and against ROS burst inflicted by neutrophil extracellular traps. By suppressing ER-resident GRP78 activity and expression, EGCG can potentially inhibit SARS-CoV-2 life cycle. EGCG also shows protective effects against 1) cytokine storm-associated acute lung injury/acute respiratory distress syndrome, 2) thrombosis via suppressing tissue factors and activating platelets, 3) sepsis by inactivating redox-sensitive HMGB1, and 4) lung fibrosis through augmenting Nrf2 and suppressing NF-κB. These activities remain to be further substantiated in animals and humans. The possible concerted actions of EGCG suggest the importance of further studies on the prevention and treatment of COVID-19 in humans. These results also call for epidemiological studies on potential preventive effects of green tea drinking on COVID-19.
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影响因子：
4.8
作者：
Dimcheff, DE;Faasse, MA;Portis, JL
通讯作者：
Portis, JL
DOI：
10.1093/jn/138.9.1677
发表时间：
2008-09
期刊：
The Journal of nutrition
影响因子：
--
作者：
Bose M;Lambert JD;Ju J;Reuhl KR;Shapses SA;Yang CS
通讯作者：
Yang CS
影响因子：
4.8
作者：
De Flora, Silvio;Balansky, Roumen;La Maestra, Sebastiano
通讯作者：
La Maestra, Sebastiano
影响因子：
--
作者：
Araneda OF;Tuesta M
通讯作者：
Tuesta M
影响因子：
56.9
作者：
Dai, Wenhao;Zhang, Bing;Liu, Hong
通讯作者：
Liu, Hong