Changes in the peritoneal equilibration test in selected chronic peritoneal dialysis patients.
Changes in the peritoneal equilibration test in selected chronic peritoneal dialysis patients.
复制标题
选定的慢性腹膜透析患者腹膜平衡测试的变化。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. Nolph
中科院分区：
文献类型：
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作者：
W. Lo;A. Brendolan;B. Prowant;H. Moore;R. Khanna;Z. Twardowski;K. Nolph
回顾性研究了1983年至1992年期间进行两次或多次腹膜平衡试验（PET）的55例慢性腹膜透析患者，平均间隔为21.9 +/- 22.7个月。当怀疑转运改变时进行重复PET，而不是常规。根据初始PET，有16个高（HI），17个高平均（HA），15个低平均（LA）和7个低（LO）转运蛋白。HI转运蛋白的平均透析液肌酐与血浆肌酐比值（D/P肌酐）显著降低，LA和LO转运蛋白升高。HI转运蛋白的平均透析液与滴注葡萄糖比率（D/Do）显著增加。个体的D/P肌酐和D/Do的变化与其各自的初始值强烈负相关。D/P肌酐和D/Do的变化彼此显著负相关，表明实际的转运变化。转运变化与腹膜炎发作或频率之间无相关性。此处描述的转运向平均值的向心[校正]变化可以解释为什么由于快速转运导致的低清除率或低超滤率是腹膜透析技术失败的罕见原因，以及为什么长期透析的患者通常是HA转运体。
Fifty-five patients on chronic peritoneal dialysis with two or more peritoneal equilibration tests (PET) performed between 1983 and 1992 with a mean interval of 21.9 +/- 22.7 months were studied retrospectively. Repeated PET were performed when transport changes were suspected rather than routinely. According to the initial PET, there were 16 high (HI), 17 high-average (HA), 15 low-average (LA), and 7 low (LO) transporters. There was a significant decrease in the mean creatinine dialysate to plasma ratio (D/P creatinine) in the HI transporters and an increase in the LA and LO transporters. The mean dialysate to instilled glucose ratio (D/Do) significantly increased in the HI transporters. The change in both the D/P creatinine and the D/Do of an individual strongly and inversely correlated to their respective initial values. The change in D/P creatinine and D/Do were significantly and inversely correlated to each other, indicating an actual transport change. No correlation was found between the change in transport with peritonitis episodes or frequencies. The centripetal [corrected] change of transport toward average described here may explain why low clearances or low ultrafiltration rates due to rapid transport are infrequent causes of peritoneal dialysis technique failure, and why patients who have been dialyzed for a long period are usually HA transporters.