CEREBRAL BLOOD-FLOW IN PRETERM INFANTS DURING THE 1ST WEEK OF LIFE
CEREBRAL BLOOD-FLOW IN PRETERM INFANTS DURING THE 1ST WEEK OF LIFE
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DOI：
10.1111/j.1651-2227.1986.tb10155.x
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
GREISEN, G
中科院分区：
文献类型：
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作者：
GREISEN, G
42例妊娠28-33周的早产儿在出生后第一周内通过静脉注射133-氙清除率进行研究，以估计总体脑血流量。对胸部检测到的计数率进行胸壁贡献校正，并用作动脉输入函数。氙的新生儿血脑分配系数用于计算平均流量估计值（CBF-无穷大）。通过使用不同获得的动脉输入函数对该技术进行了内部验证。在11名无呼吸窘迫的婴儿中，CBF-. infin。为19.8 ml/100 g/min ±。5.3 SD.在24例接受机械通气治疗的婴儿中，CBF-.为11.8 ml/100 g/min ±。3.2 SD.在7名接受持续气道正压通气治疗的婴儿中，CBF-.为21.3 ml/100 g/min ±。12.0 SD.当CBF-.考虑到与机械通气相关，9例室管膜下/脑室内出血的婴儿CBF-. infin.增加。分析了胎龄、出生体重、分娩方式、出生后年龄、平均动脉压、PaCO 2、血红蛋白和苯巴比妥药物的影响，发现不一致。总之，CBF低于预期，需要机械通气的婴儿的CBF值更低。
Forty-two preterm infants of 28-33 weeks of gestation were studied once during the first week of life by 133-Xenon clearance after intravenous injection to estimate global cerebral blood flow. Count rates detected over the chest were corrected for chest wall contribution and used as arterial input function. A neonatal blood-brain partition coefficient of Xenon was used for the calculation of a mean flow estimator (CBF-.infin.). The technique was internally validated by use of differently obtained arterial input functions. In 11 infants without respiratory distress, CBF-.infin. was 19.8 ml/100 g/min .+-. 5.3 SD. In 24 infants treated with mechanical ventilation CBF-.infin. was 11.8 ml/100 g/min .+-. 3.2 SD. In 7 infants treated with continuous positive airway pressure CBF-.infin. was 21.3 ml/100 g/min .+-. 12.0 SD. When the reduction of CBF-.infin. associated with mechanical ventilation was taken into account, the 9 infants with subependymal/intraventricular haemorrhage had increased CBF-.infin.. The effects of gestational age, birthweight, mode of delivery, postnatal age, mean arterial blood pressure, PaCO2, blood haemoglobin and phenobarbitone medication were also analyzed and found inconsistent. In conclusion, CBF was lower than expected and in infants requiring mechanical ventilation the values were lower still.