Plasmodium Sporozoite Biology
Plasmodium Sporozoite Biology
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DOI：
10.1101/cshperspect.a025478
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发表时间：
2017-05-01
影响因子：
5.4
通讯作者：
Matuschewski, Kai
中科院分区：
文献类型：
--
作者：
Frischknecht, Friedrich;Matuschewski, Kai
疟原虫子孢子传播是寄生虫生命周期进展中的关键群体瓶颈，因此是预防药物和疫苗的目标。候选抗子孢子亚单位疫苗制剂获得许可的最新进展突出了子孢子传播干预在疟疾控制组合中的重要性。子孢子定殖于蚊子唾液腺，通过皮肤迁移，穿透血管，破坏肝窦，并侵入肝细胞。了解介导无脊椎动物载体和脊椎动物宿主中显着子孢子旅程的分子和细胞机制可以为基于证据的下一代药物开发计划和免疫干预策略提供信息。
Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies.