Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury
Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury
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DOI：
10.1016/j.stemcr.2019.01.004
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发表时间：
2019-02
影响因子：
5.9
通讯作者：
Rujia Liao;Youchao Chen;Li Cheng;Lishi Fan;Han Chen;Yu-shan Wan;Yi You;Yanrong Zheng;Lei Jiang;Zhong Chen;Xiangnan Zhang;Weiwei Hu
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文献类型：
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作者：
Rujia Liao;Youchao Chen;Li Cheng;Lishi Fan;Han Chen;Yu-shan Wan;Yi You;Yanrong Zheng;Lei Jiang;Zhong Chen;Xiangnan Zhang;Weiwei Hu
The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to neurogenesis. H3R antagonism orH3Rgene knockout alleviated neurological injury in the late phase of TBI, and also promoted neuroblast differentiation to enhance neurogenesis through activation of the histaminergic system. Histamine H1 receptor, but not H2 receptor, in neural stem cells is shown to be essential for this promotion by usingHrh1fl/fl;NestinCreERT2andHrh2fl/fl;NestinCreERT2mice. Moreover, increase in mature and functional neurons at the penumbra area conferred by H3R antagonism was abrogated inHrh1fl/fl;NestinCreERT2mice. Taken together, H3R antagonism provides neuroprotection against TBI in the late phase through the promotion of neurogenesis, and the H1 receptor in neural stem cells is required for this action. H3R may serve as a new target for clinical treatment of TBI.
