Graphdiyne Materials as Nanotransducer for in Vivo Photoacoustic Imaging and Photothermal Therapy of Tumor
Graphdiyne Materials as Nanotransducer for in Vivo Photoacoustic Imaging and Photothermal Therapy of Tumor
复制标题
石墨炔材料作为纳米换能器用于体内光声成像和肿瘤光热治疗
DOI：
10.1021/acs.chemmater.7b01965
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发表时间：
2017-07-25
影响因子：
8.6
通讯作者：
Wang, Shu
中科院分区：
文献类型：
--
作者：
Li, Shengliang;Chen, Yanhuan;Wang, Shu
二维全碳材料因其上级性能和广阔的应用前景而备受关注。在此，我们提出了使用石墨二炔（GDY）作为光热声波纳米换能器的第一个演示，用于同时有效的光声成像（派）和光热治疗（PTT）在活的小鼠。GDY在近红外（NIR）区具有较大的消光系数，在808 nm激光照射下，不仅表现出稳定的光热性能，光热转换效率高达42%，而且具有良好的光声响应。GDY具有良好的生物相容性，经PEG修饰后可同时作为派探针和PTT试剂，并在活体小鼠体内表现出高效的光热消融癌细胞。这项工作为开发2D graphdiynes作为癌症治疗的新型治疗诊断平台开辟了一条新途径。
Two-dimensional (2D) all-carbon materials hold great fascination because of their superior properties and promising applications. Herein, we presented the first demonstration for the use of graphdiyne (GDY) as photothermo-acoustic wave nanotransducers for simultaneous effective photoacoustic imaging (PAI) and photothermal therapy (PTT) in living mice. With a large extinction coefficient in near-infrared (NIR) region, upon irradiated by 808 nm laser, GDY not only exhibits a stable photothermal performance with a high photothermal conversion efficiency of 42%, but also provides an excellent photoacoustic response. Owing to its good biocompatibility modified with PEGylation, GDY can be simultaneously used as PAI probe and PTT agent and exhibits an efficient photothermal ablation of cancer cells in living mice. This work opens a new way into the development of 2D graphdiynes as novel theranostic platform for cancer treatment.