VITILIGO-LIKE MACULES IN SYSTEMIC SCLERODERMA
VITILIGO-LIKE MACULES IN SYSTEMIC SCLERODERMA
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DOI：
10.1001/archderm.119.2.129
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
SANCHEZ, NP
中科院分区：
文献类型：
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作者：
SANCHEZ, JL;VAZQUEZ, M;SANCHEZ, NP
自上个世纪以来，系统性硬皮病中色素沉着过度和色素脱失的变化已为人所知，但其与该病发病机制的关系尚不清楚。对7例系统性硬皮病患者的色素脱失病变进行了临床、组织学、组织化学、免疫病理学和电镜研究，结果显示其改变与白癜风相似，但有细微差异。免疫学机制似乎参与了白癜风和系统性硬皮病色素脱失的诱导。
Changes of hyperpigmentation and depigmentation in systemic scleroderma have been known since the last century, but their relationship to the pathogenesis of the condition is poorly understood. Clinical, histologic, histochemical, immunopathologic and EM studies of the depigmented lesions in 7 patients with systemic scleroderma demonstrated changes similar to those of vitiligo, but with subtle differences. Immunologic mechanisms seem to be involved in the induction of depigmentation in both vitiligo and systemic scleroderma.