Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin
Remineralization of initial enamel caries in vitro using a novel peptide based on amelogenin
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使用基于釉原蛋白的新型肽对初始牙釉质龋齿进行体外再矿化
DOI：
10.1007/s11706-015-0298-4
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发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Zhang, Linglin
中科院分区：
文献类型：
--
作者：
Li, Danxue;Lv, Xueping;Zhang, Linglin
龋病是最常见的口腔疾病，发病率高，分布广，严重影响口腔及全身健康。目前的防龋措施如氟治疗、抗菌药物、中药等都存在一定的局限性。在这里，我们设计并合成了一种新的基于釉原蛋白的肽，并评估其促进初始釉质龋病变再矿化的能力。我们使用釉质块形成初始损伤，然后在肽、NaF和HEPES缓冲液的存在下进行12天的pH循环。与用HEPES处理的釉质相比，用肽或NaF处理的釉质具有更浅、更窄的损伤、更厚的矿化表面和更少的矿物质损失。该肽能促进早期釉质龋的矿化，抑制龋的进展。它是一种很有前途的防龋剂，具有多种研究前景和实际应用价值。
Dental caries is the most common oral disease with high incidence, widely spread and can seriously affect the health of oral cavity and the whole body. Current caries prevention measures such as fluoride treatment, antimicrobial agents, and traditional Chinese herbal, have limitations to some extent. Here we design and synthesize a novel peptide based on the amelogenin, and assess its ability to promote the remineralization of initial enamel caries lesions. We used enamel blocks to form initial lesions, and then subjected to 12-day pH cycling in the presence of peptide, NaF and HEPES buffer. Enamel treated with peptide or NaF had shallower, narrower lesions, thicker remineralized surfaces and less mineral loss than enamel treated with HEPES. This peptide can promote the remineralization of initial enamel caries and inhibit the progress of caries. It is a promising anti-caries agent with various research prospects and practical application value.