Miniature fiber-optic high-intensity focused ultrasound device using a candle soot nanoparticles-polydimethylsiloxane composites-coated photoacoustic lens
Miniature fiber-optic high-intensity focused ultrasound device using a candle soot nanoparticles-polydimethylsiloxane composites-coated photoacoustic lens
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采用蜡烛烟灰纳米颗粒-聚二甲基硅氧烷复合材料涂覆光声透镜的微型光纤高强度聚焦超声装置
DOI：
10.1364/oe.26.021700
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发表时间：
2018-08-20
期刊：
影响因子：
3.8
通讯作者：
Chen, Sung-Liang
中科院分区：
文献类型：
--
作者：
Li, Yao;Guo, Zhendong;Chen, Sung-Liang
提出了一种基于光声转换的小型光纤超声发射器，用于产生高强度聚焦超声（HIFU）。HIFU装置由光纤和光声透镜组成。我们开发了一个简单的制造程序，使光声透镜，这是涂有蜡烛烟灰纳米粒子聚二甲基硅氧烷复合材料。该光纤用于传输用于光声激发的脉冲激光，这通过消除自由空间光学对准的需要而促进了HIFU设备的使用。HIFU装置（直径6.5mm）产生的聚焦声压在正峰值上高达>30 MPa，在横向和轴向方向上分别具有类似于100 μ m和类似于500 μ m的紧密-6-dB聚焦体积。证明了由HIFU设备引起的声空化。微型HIFU设备便于手持操作。它为术中高精度HIFU治疗的临床应用提供了希望。它甚至可以用于进一步小型化的腔内治疗。(C)根据OSA开放获取出版协议的条款，2018年美国光学学会
We present a miniature fiber-optic ultrasound transmitter for generating high-intensity focused ultrasound (HIFU) based on photoacoustic transduction. The HIFU device consists of a fiber and a photoacoustic lens. We develop a simple fabrication procedure for making the photoacoustic lens, which is coated with candle soot nanoparticlespolydimethylsiloxane composites. The fiber is used to deliver pulsed laser for photoacoustic excitation, which facilitates the use of the HIFU device by eliminating the need of free-space optical alignment. The HIFU device (6.5 mm in diameter) produces focused acoustic pressures up to >30 MPa in peak positive with a tight -6-dB focal volume of similar to 100 mu m and similar to 500 mu m in the lateral and axial directions, respectively. Acoustic cavitation induced by the HIFU device is demonstrated. The miniature HIFU device facilitates handheld operation. It holds promise for clinical applications in intraoperative high-precision HIFU therapy. It can even be used for intracavitary therapy with further miniaturization. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement