Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong
Increase in the nasopharyngeal carriage of non-vaccine serogroup 15 Streptococcus pneumoniae after introduction of children pneumococcal conjugate vaccination in Hong Kong
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DOI：
10.1016/j.diagmicrobio.2014.11.006
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发表时间：
2015-02-01
影响因子：
2.9
通讯作者：
Chow, Kin-Hung
中科院分区：
文献类型：
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作者：
Ho, Pak-Leung;Chiu, Susan S.;Chow, Kin-Hung
这项研究评估了香港常规使用13价肺炎球菌结合疫苗（PCV 13）后早期的肺炎球菌携带情况。从1110名儿童（≥ 1剂PCV，15.3%的儿童≥ 3剂PCV）中获得鼻咽拭子。非PCV 13血清型占所有分离株的56.4%。最常见的血清群/型为15（15 A，5.1%; 15 B，10.3%; 15 C，9.6%; 15 F，0.6%）、19 F（17.9%）、6A（7.1%）和6C（7.1%）。血清群15的携带在接种疫苗的儿童中更常见（4.1%对0.6%，I）= 0.033）。分子分型显示，几个克隆（克隆复合体、CC 63、CC 199、CC 1262、CC 3397）的扩增是导致血清群15增加的原因。几乎所有的CC 63和CC 3397菌株对青霉素和红霉素均不敏感。这一发现强调了使用PCV 13后血清组15的出现。(C)2015 Elsevier Inc. All rights reserved.
This study assessed pneumococcal carriage in the early periods after routine use of 13-valent pneumococcal conjugate vaccine (PCV13) in Hong Kong. Nasopharyngeal swabs were obtained from 1110 children (= 1 PCV dose and 15.3% in children who had >= 3 PCV doses. Nonv-PCV13 serotypes comprised 56.4% of all isolates. The most common serogroup/types were 15 (15A, 5.1%; 15B, 10.3%; 15C, 9.6%; 15F, 0.6%), 19F (17.9%), 6A (7.1%) and 6C (7.1%). Carriage of serogroup 15 was more common among vaccinated children (4.1% versus 0.6%, I) = 0.033). Molecular typing revealed that expansion of several clones (clonal complex, CC63, CC199, CC1262, CC3397) was responsible for the increase in serogroup 15. Almost all CC63 and CC3397 isolates were nonsusceptible to both penicillin and erythromycin. The finding highlights the emergence of serogroup 15 following PCV13 use. (C) 2015 Elsevier Inc. All rights reserved.