Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study
Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study
复制标题
无先兆偏头痛中白质轴突损失：基于束的空间统计研究
DOI：
10.1177/0333102412466964
复制
发表时间：
2013-01-01
期刊：
影响因子：
4.9
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Yu, Dahua;Yuan, Kai;Tian, Jie
目的：多项扩散张量成像（DTI）衍生指数有助于推断无先兆偏头痛患者（MWoA）全脑白色改变的病理生理类型，并提供更特异的WM神经病理学生物标志物。结果：与健康对照组相比，MWoA患者多个脑区的各向异性分数（FA）、平均弥散度（MD）、径向弥散度（RD）和轴向弥散度（AD）均显著降低，而RD无显著性差异。具体而言，与健康对照组相比，MWoA患者的下FA、MD和AD在胼胝体（CC）、内囊右前肢（ALIC）和内囊后肢（PLIC）的腹侧、体部和压部中存在重叠。此外，上述WM的一些结果与MWoA.Conclusion的持续时间和头痛频率显着相关：鉴于减少AD可能表明轴突损失，我们的研究结果可能揭示轴突损失MWoA。
Aim: Multiple diffusion tensor imaging (DTI) derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of migraine patients without aura (MWoA).Methods: Twenty MWoA and 20 age-, education-and gender-matched healthy volunteers participated in this study. Tract-based spatial statistics (TBSS) was employed to investigate the WM abnormalities in MWoA by integrating multiple indices, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD).Results: Compared with healthy controls, MWoA showed significantly lower FA, MD and AD in multiple brain regions, whereas no difference in RD was observed. Specifically, the overlap among the lower FA, MD, and AD was found in the genu, body, and splenium part of the corpus callosum (CC), the right anterior limb of the internal capsule (ALIC) and the posterior limb of the internal capsule (PLIC) in MWoA compared with healthy controls. Additionally, some of the above WM findings were significantly correlated with duration and headache frequency in MWoA.Conclusion: Given that decreased AD may suggest axonal loss, our findings may reveal axonal loss in MWoA.