The role of ethanol availability on stress-induced increases in ethanol consumption
The role of ethanol availability on stress-induced increases in ethanol consumption
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DOI：
10.1016/s0741-8329(96)00046-8
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发表时间：
1997-11-01
期刊：
影响因子：
2.3
通讯作者：
Amit, Z
中科院分区：
文献类型：
--
作者：
Bowers, WJ;Sabongui, AG;Amit, Z
暴露于压力源可以增加乙醇的消耗，乙醇可以减弱压力源的行为和生化影响。本研究确定是否乙醇的可用性期间暴露于重复约束改变应激后增加乙醇摄入量。7天的约束增加乙醇摄入量的第一次后应激试验中，只有在动物的约束期间剥夺乙醇。这些结果表明，乙醇的可用性在暴露于约束可以减弱约束对乙醇摄入量的影响。乙醇摄入量也呈正相关，新奇诱导的运动和限制消除这种关系。然而，安非他明诱导的运动没有改变无论是约束或乙醇摄入。这些结果表明，自愿乙醇摄入量可以减弱束缚应激的影响，束缚应激可以改变乙醇对新奇诱导运动的影响。有人建议，乙醇摄入量和约束压力之间的这种对称关系可能涉及的互动方式，确定应力引起的乙醇消费。(C)1997年爱思唯尔科学公司
Exposure to stressors can increase ethanol consumption and ethanol can attenuate the behavioral and biochemical effects of stressors. This study determined whether the availability of ethanol during the period of exposure to repeated restraint alters the poststress increase in ethanol intake. Seven days of restraint increased ethanol intake on the first poststress test only in animals deprived of ethanol during the restraint period. These results indicate that the availability of ethanol during exposure to restraint can attenuate the impact of restraint on ethanol intake. Ethanol intake was also positively related to novelly-induced locomotion and restraint eliminated this relationship. However, amphetamine-induced locomotion was not altered by either restraint or EtOH intake. These results indicate that voluntary ethanol intake can attenuate the impact of restraint stress and that restraint stress can alter the influence of ethanol on novelty-induced locomotion. It is suggested that this symmetrical relationship between ethanol intake and restraint stress may be involved in an interactive manner that determines stress-induced ethanol consumption. (C) 1997 Elsevier Science Inc.