Neonatal auditory activation detected by functional magnetic resonance imaging
Neonatal auditory activation detected by functional magnetic resonance imaging
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DOI：
10.1016/s0730-725x(00)00231-9
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发表时间：
2001-01-01
影响因子：
2.5
通讯作者：
Ment, LR
中科院分区：
文献类型：
--
作者：
Anderson, AW;Marois, R;Ment, LR
本研究的目的是检测听觉皮层激活非镇静新生儿采用功能性磁共振成像（fMRI）。使用回波平面功能脑成像，受试者呈现调频纯音; BOLD信号响应映射在平行于上级颞回的5 mm厚切片中。20例足月健康新生儿（13例足月，7例早产）和4例成人对照受试者。血氧水平依赖（BOLD）信号的听觉刺激的检测在所有4个成人和14的20个新生儿。成年受试者的功能磁共振成像研究表明，在听觉刺激过程中，在上级颞区的信号增加。与此相反，信号下降检测在听觉刺激的14个新生儿BOLD反应中的9个。功能磁共振成像可用于检测人类婴儿在听觉刺激下的大脑激活。(C)2001 Elsevier Science Inc. All rights reserved.
The objective of this study was to detect auditory cortical activation in non-sedated neonates employing functional magnetic resonance imaging (fMRI). Using echo-planar functional brain imaging, subjects were presented with a frequency-modulated pure tone; the BOLD signal response was mapped in 5 mm-thick slices running parallel to the superior temporal gyrus. Twenty healthy neonates (13 term, 7 preterm) at term and 4 adult control subjects. Blood oxygen level-dependent (BOLD) signal in response to auditory stimulus was detected in all 4 adults and in 14 of the 20 neonates. FMRI studies of adult subjects demonstrated increased signal in the superior temporal regions during auditory stimulation. In contrast,signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants. (C) 2001 Elsevier Science Inc. All rights reserved.