The staphylococcal fibronectin receptor: evidence for its importance in invasive infections.
The staphylococcal fibronectin receptor: evidence for its importance in invasive infections.
复制标题
葡萄球菌纤连蛋白受体：其在侵袭性感染中重要性的证据。
DOI：
10.1093/clinids/9.supplement_4.s355
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Proctor,RA
中科院分区：
文献类型：
--
作者：
Proctor,RA
纤连蛋白特异性地和金黄色葡萄球菌不可逆地结合。纤维连接蛋白结合位点的表达与分离株的侵袭性相关。有研究表明，S.金黄色葡萄球菌是位于细菌表面的蛋白质或碳水化合物，允许细菌与宿主的纤连蛋白相互作用。在哪些网站S。金黄色葡萄球菌典型启动的感染富含纤连蛋白，例如，血凝块和内皮下;完整内皮的腔表面的细胞是相对缺乏纤连蛋白的少数细胞类型之一。从S.通过机械方法或通过在含抗生素的培养基中培养细菌来降低它们的粘附能力。因此，纤连蛋白受体似乎在S.金色感染。这些发现为研制预防侵袭性疾病的疫苗提供了希望--如果S.金纤连蛋白受体可以被纯化，证明是免疫原性的，并抑制细菌粘附到宿主组织。
Fibronectin binds specifically and irreversibly toStaphylococcus aureus. The expression of fibronectin-binding sites correlates with the invasivenessof the isolate. It has been suggested that the fibronectin receptor ofS. aureusis either a protein or a carbohydrate that localizes at the surface of the bacterium, permitting interactions of the bacteria with the fibronectin of the host. Sites at whichS. aureustypically initiates infection are rich in fibronectin, e.g., blood clots and subendothelium; the cells of the luminal surface of intact endothelium are among the few cell types that are relatively devoid of fibronectin. Removal of fibronectin receptors fromS. aureusby mechanical means or by growing the bacteria in an antibiotic-containing medium decreases their ability to adhere. Thus, the fibronectin receptor appears to playa role in the initiation ofS. aureusinfections. These findings offer hope for the development of a vaccine that will prevent invasive disease - if theS. aureusfibronectin receptor(s) can be purified, proves to be immunogenic, and inhibits bacterial adherence to host tissues.