Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma
Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma
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DOI：
10.1016/j.humpath.2007.05.011
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发表时间：
2008-01-01
期刊：
影响因子：
3.3
通讯作者：
Guan, Xin-Yuan
中科院分区：
文献类型：
--
作者：
Xie, Dan;Ma, Ning-Fang;Guan, Xin-Yuan
然而，eIF-5A 2在结直肠癌中的表达尚不清楚。本研究应用荧光原位杂交和免疫组织化学技术，对139例大肠癌及其癌旁正常粘膜、22例癌前腺瘤和42例转移性大肠癌组织中eIF-5A 2的扩增和过表达进行了研究。免疫组化结果显示，EIF-5A 2在正常大肠粘膜、大肠腺瘤、大肠癌和大肠转移瘤中的表达率分别为35.3%、53.2%和67.6%。15.8%（16/101）的大肠癌组织中存在eIF-5A 2扩增，且大多数大肠癌组织中EIF-5A 2过表达。在原发性结直肠癌中，EIF-5A 2在有淋巴管浸润的结直肠癌中的过表达率（61.2%）显著高于无淋巴管浸润的结直肠癌（36.6%，P
Abnormalities of eIF-5A2, however, in colorectal carcinoma are unclear. In this study, amplification and overexpression of eIF-5A2 in colorectal carcinoma were studied by fluorescence in situ hybridization and immunohistochemistry using colorectal carcinoma tissue inicroarrays, including 139 primary colorectal carcinomas and their adjacent normal mucosa, 22 paired premalignant adenomas, and 42 metastatic tumors. The immunohistochemistry results showed that overexpression of EIF-5A2 was detected in none of normal epithelial mucosa, 35.3% of colorectal adenomas, 53.2% of primary colorectal carcinomas, and 67.6% of metastases. Amplification of eIF-5A2 was detected in 15.8% (16/101) of informative colorectal carcinomas, and most of them showed overexpression of EIF-5A2. In primary colorectal carcinomas, the frequency of EIF-5A2 overexpression was significantly higher in colorectal carcinomas with lymphovascular invasion (61.2%) than that in colorectal carcinomas without lymphovascular invasion (36.6%, P