Blood mercury concentration, fish consumption and anthropometry in Chinese children: A national study
Blood mercury concentration, fish consumption and anthropometry in Chinese children: A national study
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DOI：
10.1016/j.envint.2017.08.016
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发表时间：
2018-01-01
影响因子：
11.8
通讯作者：
Yan, Chong-Huai
中科院分区：
文献类型：
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作者：
Gao, Zhen-Yan;Li, Min-Ming;Yan, Chong-Huai
目的：方法：2013年5月至2015年3月，采用多阶段、分层、整群随机抽样方法，收集全国0 ~ 6岁儿童血汞水平及汞暴露危险因素的横断面数据，为制定降低儿童血汞水平的预防措施提供依据。选取了中国七个不同地理区域的上海、吉林、山西、广东、青海、云南和湖北作为研究场域。共有14，202名0-6岁的儿童参与了这项研究。从受试者中采集全血静脉样本（3 ml）用于汞暴露评估。应用DMA-80进行汞检测，在研究者的指导下，由受试者的父母完成收集相关混杂因素信息的健康问卷。一般线性模型用于主要描述性统计分析。使用无条件逻辑回归估计危险因素的比值比（OR）和95%CI。结果：共收集了14，202份合格样本。平均汞含量为1.39微克/升。其他结果如下：中位数1.23 μ g/L，p25 0.86 μ g/L，p75 1.73 μ g/L，GM 1.10 μ g/L。在七个地理区域中，中国西北部的青海的汞含量中位数为0.37微克/升，明显低于中国东南部广东的汞含量（2.01微克/升）。郊区儿童血汞中位数为1.34 μ g/L，显著高于农村儿童血汞中位数（1.09 μ g/L）。使用中位汞浓度生成二分亚组。非条件Logistic回归分析显示，鱼类消费可能有助于增加血汞水平（p < 0.05）。此外，我们观察到汞浓度和儿童的人体测量特征（BMI; p < 0.05）之间的显着正相关。结论：中国0-6岁儿童的血汞浓度被认为是低的，和儿童谁消耗更多的海水鱼，淡水鱼和贝类往往有较高的汞浓度。我们的研究表明，儿童的生长可能受到汞的积极影响，这可能会影响鱼类消费的积极影响。
Objective: This study sought to obtain national cross-sectional data for blood mercury levels and risk factors for mercury exposure in Chinese children aged 0 to 6 years to provide evidence to support preventive measures for reducing childhood blood mercury levels.Methods: A multi-stage, stratified, clustered random sampling survey was conducted May 2013-Mar 2015. Shanghai, Jilin, Shanxi, Guangdong, Qinghai, Yunnan and Hubei, which are located in seven different geographical regions in China, were selected as the study field. A total of 14,202 children aged 0-6 years participated in the study. Whole-blood venous samples (3 ml) were collected from the subjects for mercury exposure assessment. The DMA-80 was applied for mercury detection, and a health questionnaire gathering information on related confounders was completed by the subjects' parents of the subjects after they received guidance from the investigators. A general linear model was used for the primary descriptive statistical analysis. Odds ratios (ORs) and 95% CIs for the risk factors were estimated using unconditional logistic regression.Results: A total of 14,202 eligible samples were collected. The mean mercury level was 1.39 mu g/L. Other results were as follows: median 1.23 mu g/L, p25 0.86 mu g/L, p75 1.73 mu g/L, and GM 1.10 mu g/L. Of the seven geographical regions, Qinghai, in northwestern China, had a median mercury level of 0.37 mu g/L, which was significantly lower than the mercury level in Guangdong, in southeastern China (2.01 mu g/L). The median blood mercury level of children in suburban areas was 1.34 mu g/L, which was remarkably higher than that of children in rural areas (1.09 mu g/L). Dichotomous subgroups were generated using the median mercury concentration. Unconditional logistic regression analysis revealed that fish consumption may contribute to increased blood mercury levels (p < 0.05). Additionally, we observed significantly positive associations between mercury concentrations and the children's anthropometric characteristics (BMI; p < 0.05).Conclusions: Blood mercury concentrations among Chinese children aged 0-6 years were considered low, and children who consumed more marine fish, freshwater fish and shellfish tended to have higher mercury concentrations. Our study suggests that children's growth is likely affected by the positive effects of mercury, which may have implications concerning the positive effects of fish consumption.