ON THE COMPETITION BETWEEN METABOLIC VASODILATATION AND NEUROGENIC VASOCONSTRICTION IN SKELETAL MUSCLE.
ON THE COMPETITION BETWEEN METABOLIC VASODILATATION AND NEUROGENIC VASOCONSTRICTION IN SKELETAL MUSCLE.
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关于骨骼肌代谢性血管舒张和神经源性血管收缩之间的竞争。
DOI：
10.1111/j.1748-1716.1965.tb04088.x
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
I. Kjellmer
中科院分区：
文献类型：
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作者：
I. Kjellmer
采用体积描记法，结合血流记录，有时还用同位素技术记录猫小腿的血容量，研究了当血管受到肌肉运动和血管收缩纤维活性的拮抗影响时，阻力血管、毛细血管过滤系数和电容血管的反应。
在较高频率的刺激下，交感神经激活导致运动期间与休息期间同样显着的血流量减少，但在运动期间，尽管持续刺激，阻力血管的反应在几分钟内消退，稳定在仅略高于起始水平的水平。运动过程中已经增加的毛细血管过滤系数受到影响，只有当交感神经受到明显阻碍血流的频率刺激时，毛细血管过滤系数才会进一步增加。运动期间的交感神经刺激会增加电容血管的张力，这种反应根本不会像阻力血管那样减弱。
结论是，阻力血管，特别是毛细血管前括约肌对运动期间局部释放的血管舒张代谢物比对血管收缩纤维供应更敏感，而电容血管则相反。
Using a plethysmographic method combined with recording of blood flow and, at times, recording of the volume of blood in the calf of the cat with an isotope technique, the responses of the resistance vessels, of the capillary filtration coefficient and of the capacitance vessels were studied when the vessels were subjected to the antagonistic influences of muscular exercise and vasoconstrictor fibre activity.
At the higher frequencies of stimulation used sympathetic activation caused an equally marked reduction of blood flow during exercise as during rest, but during exercise the response of the resistance vessels subsided within a few minutes to become steady at a level only a little above starting level despite continued stimulation. The capillary filtration coefficient, already increased during exercise, was affected, and then increased still further only when the sympathetic were stimulated at such frequencies as impeded blood flow markedly. Sympathetic stimulation during exercise increased the tone of the capacitance vessels—a response that did not weaken at all so soon as that of the resistance vessels.
It is concluded that the resistance vessels and particularly the precapillary sphincters are more sensitive to vasodilator metabolites locally released during exercise than to the vasoconstrictor fibre supply, while the reverse is true for the capacitance vessels.