Glucocorticoid use represents a risk factor for central serous chorioretinopathy: a prospective, case-control study
Glucocorticoid use represents a risk factor for central serous chorioretinopathy: a prospective, case-control study
复制标题
DOI：
10.1007/s00417-004-0885-z
复制
发表时间：
2004-09-01
影响因子：
2.7
通讯作者：
Bouzas, EA
中科院分区：
文献类型：
--
作者：
Karadimas, P;Bouzas, EA
目的：评价糖皮质激素暴露是否为中枢性浆液性脉络膜视网膜病变（CSCR）发展的危险因素。方法：前瞻性病例对照研究。38名连续的急性CSCR患者被要求回答一份关于在症状出现前的最后一个月以任何形式使用糖皮质激素的具体问卷。同时还招募了一个年龄和性别匹配的对照组。它包括在门诊就诊的非CSCR患者，他们被要求回答相同的问卷。结果：38例CSCR患者中有11例（28.9%）使用糖皮质激素；其中8名男性，3名女性。在对照组中，38例患者中有2例（5.2%）使用糖皮质激素，1男1女。两组间差异有统计学意义（优势比=7.33,95% CI=1.49 ~ 35.85， P=0.006）。结论：在这项前瞻性的病例对照研究中，我们发现糖皮质激素的使用是CSCR发生的一个危险因素。
Purpose: To evaluate whether exposure to glucocorticoids represents a risk factor for the development of central serous chorioretinopathy (CSCR). Methods: Prospective, case-control study. Thirty-eight consecutive patients with acute CSCR were asked to answer a specific questionnaire regarding the use of glucocorticoids, in any form, during the last month before the onset of the symptoms. An age- and sex-matched control group was also recruited. It consisted of patients attending the outpatient department for a condition other than CSCR, who were asked to answer the same questionnaire. Results: Use of glucocorticoids was recorded in 11 of 38 patients (28.9%) with CSCR; 8 of them were men and 3 women. In the control group, use of glucocorticoids was recorded in 2 of 38 patients (5.2%), 1 man and 1 woman. The difference between the two groups is statistically significant (odds ratio=7.33, 95% CI=1.49-35.85, P=0.006). Conclusion: In this prospective, case-control study, we found that glucocorticoid use represents a risk factor for the development of CSCR.