Coronary MR Imaging: Effect of Timing and Dose of Isosorbide Dinitrate Administration
Coronary MR Imaging: Effect of Timing and Dose of Isosorbide Dinitrate Administration
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DOI：
10.1148/radiol.09090483
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发表时间：
2010-02-01
期刊：
影响因子：
19.7
通讯作者：
Nezafat, Reza
中科院分区：
文献类型：
--
作者：
Hu, Peng;Chuang, Michael L.;Nezafat, Reza
目的：量化舌下硝酸异山梨酯（ISDN）管理冠状动脉磁共振（MR）imaging.Materials and Methods的影响：书面知情同意书，从所有参与者，并通过机构审查委员会批准了符合健康保险责任法案的协议。应用ISDN前后在1.5T条件下进行冠状动脉MR成像（2.5或5 mg），25名健康成人志愿者（平均年龄：23岁± 4岁; 9名男性，16名女性），（n = 20，随机分为四组）或全心脏（n = 5）采集梯度回波（GRE）或平衡稳态自由进动（SSFP）序列。图像质量由两名心脏病专家在四分量表上进行评估。对信噪比（SNR）、血管直径和血管清晰度进行了表征。采用线性混合效应模型进行数据分析。P值小于0.05被认为是指示显著差异。结果：5 mg ISDN的最大SNR增强（GRE：22.0% +/- 10.7%; SSFP：20.1% +/- 6.0%）与2.5 mg（GRE：21.9% +/- 5.4%; SSFP：19.1% +/- 3.0%）相似（P > .05）。然而，5 mg剂量达到最大SNR增强的时间（15.5分钟+/- 6.0）比2.5 mg剂量（23.5分钟+/- 6.7）更早（P <0.01）。5 mg ISDN组血管直径的增加大于2.5 mg ISDN组（GRE和SSFP序列均P <0.05）。应用ISDN后冠状动脉图像更清晰（P < .03）。在ISDN给药后，GRE图像的主观图像质量评分显著改善（两种剂量P <0.05），但SSFP图像相似（2.5 mg P = 0.24; 5 mg P = 0.27）。结论：舌下含服ISDN可提高冠状动脉MR成像信噪比。医师在进行冠状动脉MR成像时需要考虑ISDN的剂量和时间效应。
Purpose: To quantify the effect of sublingual isosorbide dinitrate ( ISDN) administration on coronary magnetic resonance (MR) imaging.Materials and Methods: Written informed consent was obtained from all participants, and the HIPAA-compliant protocol was approved by the Institutional Review Board. Coronary MR imaging was performed at 1.5 T before and after administration of ISDN (2.5 or 5 mg) in 25 healthy adult volunteers (mean age, 23 years +/- 4; nine men, 16 women) with three-dimensional targeted (n = 20, randomized into four groups) or whole-heart ( n = 5) acquisitions with gradient-recalled echo (GRE) or balanced steady-state free precession (SSFP) sequences. Image quality was assessed by two cardiologists on a four-point scale. Signal-to-noise ratio (SNR), vessel diameter, and vessel sharpness were characterized. A linear mixed-effects model was used for data analysis. A P value of less than .05 was considered to indicate a significant difference.Results: The maximum SNR enhancement with 5 mg of ISDN (GRE: 22.0% +/- 10.7%; SSFP: 20.1% +/- 6.0%) was similar (P > .05) to that with 2.5 mg (GRE: 21.9% +/- 5.4%; SSFP: 19.1% +/- 3.0%). However, the time to maximum SNR enhancement for the 5-mg dose (15.5 minutes +/- 6.0) was earlier (P < .01) than that for 2.5 mg (23.5 minutes +/- 6.7). The increase in vessel diameter with 5 mg of ISDN was greater than that with 2.5 mg (P < .05 for both GRE and SSFP sequences). The coronary images were sharper after ISDN administration (P < .03). Subjective image quality score significantly improved after ISDN administration for GRE images (P < .05 for both doses) but was similar for SSFP images (P = .24 for 2.5 mg; P = .27 for 5 mg). Whole-heart coronary SNR was improved about 10% after ISDN administration (P < .05).Conclusion: Sublingual ISDN improves coronary MR imaging SNR. Practitioners need to consider the dose and temporal effects of ISDN when performing coronary MR imaging.