SLE-Associated Defects Promote Altered T Cell Function.
SLE-Associated Defects Promote Altered T Cell Function.
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DOI：
10.1615/critrevimmunol.2018025213
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发表时间：
2017
影响因子：
1.3
通讯作者：
Tsokos GC
中科院分区：
文献类型：
--
作者：
Crispin JC;Hedrich CM;Suárez-Fueyo A;Comte D;Tsokos GC
系统性红斑狼疮(SLE)是一种与T淋巴细胞功能和表型严重缺陷有关的慢性自身免疫性疾病。在这里，我们描述已被记录在SLE患者T细胞中的异常信号通路，并讨论它们如何影响基因表达和免疫功能，以了解它们如何在疾病的发生和发展中起作用。
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.