Phase-contrast diffuse optical tomography: Pilot results in the breast
Phase-contrast diffuse optical tomography: Pilot results in the breast
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DOI：
10.1016/j.acra.2008.01.028
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发表时间：
2008-07-01
影响因子：
4.8
通讯作者：
Jiang, Huabei
中科院分区：
文献类型：
--
作者：
Liang, Xiaoping;Zhang, Qizhi;Jiang, Huabei
理由和目标。我们试图调查的实用程序相衬扩散光学断层扫描（PCDOT）的恶性和良性乳腺肿块在人类的分化，并比较PCDOT与传统的扩散光学断层扫描（DOT）的乳腺肿块在human.Materials和Methods的分析。使用PCDOT对33例患者（平均年龄51岁，范围22-80岁）的35个乳腺肿块进行成像。图像特征的组织折射率，吸收和散射系数的乳腺肿块得到了基于有限元重建算法。对所有病例的图像进行分析，并与活检/病理结果进行比较。恶性病变往往有一个降低的折射率，使他们能够区分良性病变在大多数情况下，而吸收和散射图像无法准确地区分良性病变恶性病变。屈光指数成像的敏感性、特异性、假阳性率和总体准确性分别为81.8%、70.8%、29.2%和74.3%。随着年龄的增长，屈光指数成像的准确性也随之增加。折射率是一个新的光学成像参数，可能有助于区分乳腺良恶性肿块。
Rationale and Objectives. We sought to investigate the utility of phase-contrast diffuse optical tomography (PCDOT) for differentiation of malignant and benign breast masses in humans and to compare PCDOT with conventional diffuse optical tomography (DOT) for analysis of breast masses in humans.Materials and Methods. Thirty-five breast masses were imaged in 33 patients (mean age, 51 years; range, 22-80) using PCDOT. Images characterizing the tissue refractive index, and absorption and scattering coefficients of breast masses were obtained with a finite element-based reconstruction algorithm. Theses images were then analyzed and compared with the biopsy/pathology results for all the cases examined.Results. Malignant lesions tended to have a decreased refractive index, allowing them to be discriminated from benign lesions in most cases, whereas absorption and scattering images were unable to accurately discriminate benign from malignant lesions. The sensitivity, specificity, false-positive value, and overall accuracy for refractive index imaging were 81.8%, 70.8%, 29.2%, and 74.3%, respectively. The accuracy of refractive index imaging increases with increasing patient age.Conclusion. Refractive index is a new parameter for optical imaging that may be helpful in differentiating between malignant and benign masses in the breast.