Bmp7 mediates early signaling events during induction of chick epidermal organs
Bmp7 mediates early signaling events during induction of chick epidermal organs
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DOI：
10.1002/dvdy.20096
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发表时间：
2004-09-01
影响因子：
2.5
通讯作者：
Fallon, JF
中科院分区：
文献类型：
--
作者：
Harris, MP;Linkhart, BL;Fallon, JF
大量脊椎动物器官的诱导和特化需要上皮细胞和间充质之间的相互信号传导。在表皮器官的形成中，导致器官原基形成的初始诱导信号事件源于间充质。然而，上皮细胞必须有能力对这些信号作出反应。我们证明，骨形态发生蛋白7（BMP 7）是一个早期的分子标记表皮器官发育过程中的羽毛和鳞片的小鸡。BMP 7在前基板表皮中广泛表达，随后定位于羽毛和鳞片的形成基板。无鳞突变体鸡体壁中Bmp 7表达的检查表明，表皮中Bmp 7的表达与形成表皮器官的能力相关。我们表明，BMP 7的功能是必要的，在羽毛和鳞片形成表皮的表皮基板的形成。此外，Bmp 7在Silkie突变体的跖骨表皮中的早熟表达或用异位BMP 7蛋白处理跖骨导致从鳞片形成珠被的羽毛发育。从这些数据中，我们提出，BMP 7是必要的和足够的，在发展的背景下，介导的上皮细胞的能力，以响应从底层间充质的诱导信号，形成在小鸡的表皮器官。我们建议，在胚胎表皮的局部区域的BMP 7的调节促进区域形成的表皮器官的发展。(C)2004威利-利斯公司
The induction and specification of a large number of vertebrate organs require reciprocal signaling between an epithelium and subjacent mesenchyme. In the formation of integumentary organs, the initial inductive signaling events leading to the formation of the organ primordia stem from the mesenchyme. However, the epithelium must have the capacity to respond to these signals. We demonstrate that bone morphogenetic protein 7 (Bmp7) is an early molecular marker for epidermal organ development during development of feathers and scales of the chick. Bmp7 is expressed broadly in the preplacode epidermis and subsequently becomes localized to the forming placodes of feathers and scales. An examination of Bmp7 expression in the scaleless mutant chicken integument indicates that Bmp7 expression in the epidermis is associated with the ability to form epidermal organs. We show that BMP7 function is necessary for the formation of epidermal placodes in both feather and scale forming epidermis. In addition, precocious expression of Bmp7 in the metatarsal epidermis of the Silkie mutant or treatment of the metatarsus with ectopic BMP7 protein results in feather development from scale forming integument. From these data, we propose that Bmp7 is necessary and sufficient, in a developmental context, to mediate the competence of an epithelium to respond to inductive signals from the underlying mesenchyme to form epidermal organs in the chick. We propose that regulation of Bmp7 in localized areas of the embryonic epidermis facilitates the development of regional formation of integumentary organs. (C) 2004 Wiley-Liss, Inc.