Association Between IgA Deficiency & Other Autoimmune Conditions: A Population-Based Matched Cohort Study
Association Between IgA Deficiency & Other Autoimmune Conditions: A Population-Based Matched Cohort Study
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DOI：
10.1007/s10875-014-0009-4
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发表时间：
2014-05-01
影响因子：
9.1
通讯作者：
Hammarstrom, Lennart
中科院分区：
文献类型：
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作者：
Ludvigsson, Jonas F.;Neovius, Martin;Hammarstrom, Lennart
目的探讨IgA缺乏症患者自身免疫性疾病与普通人群的比较。方法全国前瞻性人群队列研究。通过瑞典的六所大学医院，我们确定了1980年至2011年间诊断出的2100例IgA缺乏症（IgA水平< 0.07 g/L）。每个IgA缺乏症患者在年龄、性别、居住地和诊断年份上与多达10个一般人群对照（n = 18,653）相匹配。从瑞典国家患者登记册（包括住院和非初级门诊护理）检索了9种自身免疫性疾病的数据。自身免疫性疾病定义为至少两次就诊，并将相关国际疾病分类（ICD）代码列为主要诊断。计算患病率和患病率比（pr）。结果IgA缺乏的个体更容易患乳糜泻（6.7% vs.对照组0.19%）和1型糖尿病（5.9% vs. 0.57%），对应于乳糜泻的PR高35倍，1型糖尿病的PR高10倍。也为其他自身免疫性疾病我们看到统计上显著提升数据大相径庭,PRs(青少年特发性关节炎(0.76% vs 0.09%控制,公关= 8.9),系统性红斑狼疮(0.57%比0.06%;公关= 8.9),炎症性肠病(3.9%比0.81%,公关= 5.0;专门克罗恩氏病(2.4%比0.42%;公关= 5.7)和溃疡性结肠炎(1.7%比0.46%;公关= 3.9)),hypothyreosis(0.76%比0.16%;公关= 4.6),类风湿性关节炎(2.2% vs . 0.50%;PR = 4.5)和甲状腺功能亢进（1.7% vs. 0.43%; PR = 3.9），但重症肌无力不存在（0.05% vs. 0.02%; PR = 3.0）。结论：IgA缺乏症患者有较高的其他自身免疫性疾病患病率。
Purpose To examine autoimmune disorders in patients with IgA deficiency compared with the general population.Methods Nationwide prospective population-based cohort study. Through six university hospitals in Sweden we identified 2100 individuals with IgA deficiency (IgA levels < .07 g/L) diagnosed between 1980 and 2011. Each patient with IgA deficiency was matched on age, sex, place of residence, and year of diagnosis with up to 10 general population controls (n = 18,653). Data on nine autoimmune disorders were retrieved from the Swedish National Patient Register (including inpatient and non-primary outpatient care). Autoimmune disorders were defined as having at least two visits listing the relevant international classification of disease (ICD) code as main diagnosis. Prevalences and prevalence ratios (PRs) were calculated.Results Individuals with IgA deficiency more often had celiac disease (6.7 % vs. 0.19 % in controls) and type 1 diabetes (5.9 % vs. 0.57 %) corresponding to a 35-fold higher PR for celiac disease and 10-fold higher for type 1 diabetes. Also for the other autoimmune diseases did we see statistically significantly elevated prevalences and PRs (juvenile idiopathic arthritis (0.76 % vs. 0.09 % in controls, PR = 8.9), systemic lupus erythematosus (0.57 % vs. 0.06 %; PR = 8.9), inflammatory bowel disease (3.9 % vs. 0.81 %; PR = 5.0; specifically Crohn's disease (2.4 % vs. 0.42 %; PR = 5.7) and ulcerative colitis (1.7 % vs. 0.46 %; PR = 3.9)), hypothyreosis (0.76 % vs. 0.16 %; PR = 4.6), rheumatoid arthritis (2.2 % vs. 0.50 %; PR = 4.5), and hyperthyreosis (1.7 % vs. 0.43 %; PR = 3.9), but not with myasthenia gravis (0.05 % vs. 0.02 %; PR = 3.0).Conclusions Individuals with IgA deficiency have a higher prevalence of several other autoimmune disorders.