Multifunctional magnetic-fluorescent CdS@Gd-DTPA hierarchical hollow nanospheres: preparation and potential application in drug delivery
Multifunctional magnetic-fluorescent CdS@Gd-DTPA hierarchical hollow nanospheres: preparation and potential application in drug delivery
复制标题
多功能磁性荧光CdS@Gd-DTPA分级空心纳米球：制备及其在药物输送中的潜在应用
DOI：
10.1039/c3ce40534f
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发表时间：
2013
期刊：
影响因子：
3.1
通讯作者：
Liu Shiyuan
中科院分区：
文献类型：
--
作者：
Zhu Jun;Zhou Juan;Wei Daixu;Liu Shiyuan
Nearly monodisperse CdS hierarchical hollow nanospheres have been synthesized on a large scale through a Na3cit-assisted solution route. The hollow structure has an application as a drug carrier and the CdS building blocks have fluorescent capabilities. The T1-agent, Gd–DTPA, is then conjugated to the CdS hierarchical hollow nanospheres through N-ethyl-N′-[3-(dimethylamino)propyl]carbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) coupling chemistry using surface absorbed Na3cit molecules as an intermedium. Thus, multifunctional magnetic-fluorescent CdS@Gd–DTPA hierarchical hollow nanospheres are formed, which combine magnetic resonance imaging (MRI), fluorescent imaging and drug delivery into one system. The as-prepared products are characterized in detail by powder X-ray diffraction, transmission electron microscopy, scanning electron microscopy and Fourier transform infrared spectrometry. The room temperature photoluminescent spectra and T1-weighted maps of the obtained CdS@Gd–DTPA are carried out using a fluorescence spectrophotometer and a 3 T MRI scanner, respectively. The results indicate that the as-prepared product is a potential candidate for simultaneous disease diagnosis and therapy by combining the multiplexing imaging capability.
