Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis.
Evaluation of nanomaterials to prevent oral Candidiasis in PMMA based denture wearing patients. A systematic analysis.
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DOI：
10.1016/j.jobcr.2020.04.012
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发表时间：
2020-04-01
影响因子：
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通讯作者：
Khan, Zishan H
中科院分区：
文献类型：
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作者：
Ahmad, Nafis;Jafri, Zeba;Khan, Zishan H
目得：本研究的目的是通过改变纳米颗粒的表面和结晶度来预防PMMA Doppler Base上的念珠菌菌落。材料和方法：检索PubMed/Medline，以确定2011年至2020年发表的100篇相关研究。检索策略采用了以下关键词，这些关键词与“纳米颗粒在牙科中的应用”、“抗菌剂和PMMA”、“牙周炎和纳米材料”、“预防口腔牙周炎”、“在丙烯酸义齿中加入抗菌剂”、“纳米颗粒作为义齿性口炎的治疗剂”、“纳米牙科学”或“纳米技术”或“纳米复合材料”或“纳米药物”或“纳米材料”相关。大多数研究表明，含有不同抗菌涂层的改性PMMA义齿基托树脂，以及金属氧化物纳米颗粒和其他纳米材料的掺入，在体外表现出抗真菌活性;然而，一些材料在较高浓度下表现出物理和机械性能的改变，可能是由于纳米颗粒在PMMA分子晶格中的聚集。金属氧化物纳米材料对口腔生物膜（包括PMMA义齿表面）中的念珠菌和其他微生物具有细胞毒性。纳米毒性可能是由于纳米颗粒与细胞膜直接相互作用，阻碍蛋白质合成和早期粘附，干扰病原体的生理。
PURPOSE: The purpose of this study is the prevention of Candida colonies on PMMA Denture Base by altering the surface and incorporations of Nanoparticles.MATERIALS AND METHODS: The Pub Med/Medline was searched to identify 100 relevant studies published from 2011 to 2020. The search strategy employed the following keywords related to "use of Nanoparticles in dentistry", "Antimicrobial agents and PMMA", "Candidiasis and nanomaterials", "Prevention of oral Candidiasis", "Incorporation of antimicrobial agents in acrylic dentures," "nanoparticles as therapeutic agents for denture stomatitis", "Nanodentistry" or "Nanotechnology" or "Nanocomposite" or "Nanodrugs" or "Nanomaterials".RESULTS: Most of the studies shows that modified PMMA denture base resin containing different antimicrobial coatings and incorporation of metal oxides Nanoparticles and other nanomaterials showed antifungal activity in vitro; however some materials in higher concentration showing altered physical and mechanical properties possibly due to aggregation of Nanoparticles in the lattice of PMMA molecules.CONCLUSION: Metal oxides nanomaterials revealed cytotoxicity to Candida and other microbes present in oral biofilm including PMMA denture surface. Nano toxicity may attribute to direct interaction of nanoparticles with cell membrane, hindrance in protein synthesis and early adhesion & interfere with physiology of pathogens.