New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome.
New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome.
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DOI：
10.1097/bor.0000000000000201
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发表时间：
2015-09
影响因子：
5.1
通讯作者：
Anolik JH
中科院分区：
文献类型：
--
作者：
Bird AK;Meednu N;Anolik JH
我们对B细胞在系统性红斑狼疮(SLE)和干燥综合征(PSS)中的生理和致病功能的了解在不断扩大。在这篇综述中，我们讨论了最近18个月发表的关于B细胞在系统自身免疫中的作用的新见解。数据继续扩展包括Toll样受体(TLR)在内的先天性免疫信号调节B细胞室的不同机制。定位的B细胞和长寿命浆细胞在靶组织中发挥重要作用，包括肾脏和唾液腺中异位淋巴样结构的发育。除了B细胞的致病作用外，越来越多的证据表明，调节性B细胞亚群起到了保护作用，并对调节其发育的信号有了新的见解。在过去的几年中，人们对先天免疫信号导致SLE和PSS中B细胞激活的多种途径以及B细胞参与疾病表达的日益多样化的方式提供了见解。进一步了解B细胞在疾病中的保护功能和致病功能之间的失衡，包括在研究不足的靶组织中，应该会产生新的治疗方法。
Our understanding of the physiological and pathogenic functions of B cells in systemic lupus erythematosus (SLE) and Sjogren’s syndrome (pSS) continues to expand. In this review, we discuss novel insights published in the last 18 months into the roles of B cells in systemic autoimmunity. Data has continued to expand the diverse mechanisms by which innate immune signals including toll like receptors (TLR) may regulate the B cell compartment. Localized B cells and long-lived plasma cells have been identified as playing an important role in target tissue including the development of ectopic lymphoid structures in kidney and salivary gland. In addition to pathogenic roles for B cells, there is mounting evidence for regulatory B cell subsets that play a protective role and new insights into the signals that regulate their development. The past few years have provided insights into the multiple paths by which innate immune signals can lead to B cell activation in SLE and pSS and the increasingly diverse ways in which B cells contribute to disease expression. Further understanding the imbalance between protective and pathogenic functions for B cells in disease including in understudied target tissue should yield new treatment approaches.